Brain 5-lipoxygenase over-expression worsens memory, synaptic integrity, and tau pathology in the P301S mice-Reference-Cited by-同舟云学术

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Brain 5-lipoxygenase over-expression worsens memory, synaptic integrity, and tau pathology in the P301S mice

Published:2017-11-04 Issue:1 Volume:17 Page:e12695
ISSN:1474-9718
Container-title:Aging Cell
language:en
Short-container-title:Aging Cell

Author:

Vagnozzi Alana N.¹,Giannopoulos Phillip F.¹,Praticò Domenico¹

Affiliation:

1. Department of Pharmacology; Center for Translational Medicine; Lewis Katz School of Medicine; Temple University; Philadelphia PA 19140 USA

Funder

Alzheimer Art Quilt Initiative

Wanda Simone Endowment Fund for Neuroscience

Publisher

Wiley

Subject

Cell Biology,Ageing

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/acel.12695/fullpdf

Reference30 articles.

1. Tau and tauopathies;Arendt;Brain Res. Bull.,2016

2. Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein;Bellucci;Am. J. Pathol.,2004

3. The 5-lipoxygenase enzymatic pathway in the mouse brain: young versus old;Chinnici;Neurobiol. Aging,2007

4. 5-Lipoxygenase as an endogenous modulator of amyloid-β formation in vivo;Chu;Ann. Neurol.,2011a

5. Pharmacologic blockade of 5-lipoxygenase improves the amyloidotic phenotype of an Alzheimer's disease transgenic mouse model involvement of γ-secretase;Chu;Am. J. Pathol.,2011b

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