Late‐Season Influenza Vaccine Effectiveness Against Medically Attended Outpatient Illness, United States, December 2022

Late‐Season Influenza Vaccine Effectiveness Against Medically Attended Outpatient Illness, United States, December 2022–April 2023

Published:2024-06 Issue:6 Volume:18 Page:
ISSN:1750-2640
Container-title:Influenza and Other Respiratory Viruses
language:en
Short-container-title:Influenza Resp Viruses

Author:

Chung Jessie R.¹^ORCID,Shirk Philip¹,Gaglani Manjusha²³,Mutnal Manohar B.²³,Nowalk Mary Patricia⁴^ORCID,Moehling Geffel Krissy⁴,House Stacey L.⁵,Curley Tara⁵,Wernli Karen J.⁶⁷,Kiniry Erika L.⁶,Martin Emily T.⁸^ORCID,Vaughn Ivana A.⁹^ORCID,Murugan Vel¹⁰^ORCID,Lim Efrem S.¹¹,Saade Elie¹²,Faryar Kiran¹³,Williams Olivia L.¹⁴,Walter Emmanuel B.¹⁴,Price Ashley M.¹,Barnes John R.¹,DaSilva Juliana¹,Kondor Rebecca¹,Ellington Sascha¹,Flannery Brendan¹

Affiliation:

1. Influenza Division US Centers for Disease Control and Prevention Atlanta Georgia USA

2. Baylor Scott & White Health Temple Texas USA

3. Department of Pediatrics Baylor College of Medicine Temple Texas USA

4. Department of Family Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA

5. Department of Emergency Medicine Washington University School of Medicine in St. Louis St. Louis Missouri USA

6. Kaiser Permanente Washington Health Research Institute Seattle Washington USA

7. Department of Health Systems Science Kaiser Permanente Bernard J. Tyson School of Medicine Pasadena California USA

8. Department of Epidemiology University of Michigan School of Public Health Ann Arbor Michigan USA

9. Henry Ford Health Detroit Michigan USA

10. Biodesign Center for Personalized Diagnostics Arizona State University Tempe Arizona USA

11. Biodesign Center for Fundamental & Applied Microbiomics Arizona State University Tempe Arizona USA

12. Division of Infectious Diseases and HIV Medicine University Hospitals of Cleveland Cleveland Ohio USA

13. Department of Emergency Medicine University Hospitals of Cleveland Cleveland Ohio USA

14. Duke Human Vaccine Institute Duke University School of Medicine Durham North Carolina USA

Abstract

ABSTRACTBackgroundThe 2022–23 US influenza season peaked early in fall 2022.MethodsLate‐season influenza vaccine effectiveness (VE) against outpatient, laboratory‐confirmed influenza was calculated among participants of the US Influenza VE Network using a test‐negative design.ResultsOf 2561 participants enrolled from December 12, 2022 to April 30, 2023, 91 laboratory‐confirmed influenza cases primarily had A(H1N1)pdm09 (6B.1A.5a.2a.1) or A(H3N2) (3C.2a1b.2a.2b). Overall, VE was 30% (95% confidence interval −9%, 54%); low late‐season activity precluded estimation for most subgroups.Conclusions2022–23 late‐season outpatient influenza VE was not statistically significant. Genomic characterization may improve the identification of influenza viruses that circulate postinfluenza peak.

Funder

Centers for Disease Control and Prevention

National Institutes of Health

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/irv.13342

Reference15 articles.

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2. National Foundation for Infectious Diseases ”US Health Officials Urge Vaccination to Help Protect Against a Potentially Severe Flu Season ” (2022) https://www.nfid.org/us‐health‐officials‐urge‐vaccination‐to‐help‐protect‐against‐a‐potentially‐severe‐flu‐season/.

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