Affiliation:
1. The Fourth Clinical Medical College Zhejiang Chinese Medical University Hangzhou Zhejiang China
2. Department of Dermatology Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical University Hangzhou Zhejiang China
3. Department of Dermatology Hangzhou Third People‘s Hospital Hangzhou Zhejiang China
Abstract
AbstractAlopecia areata refers to an autoimmune illness indicated by persistent inflammation. The key requirement for alopecia areata occurrence is the disruption of immune‐privileged regions within the hair follicles. Recent research has indicated that neuropeptides play a role in the damage to hair follicles by triggering neurogenic inflammation, stimulating mast cells ambient the follicles, and promoting apoptotic processes in keratinocytes. However, the exact pathogenesis of alopecia areata requires further investigation. Recently, there has been an increasing focus on understanding the mechanisms of immune diseases resulting from the interplay between the nervous and the immune system. Neurogenic inflammation due to neuroimmune disorders of the skin system may disrupt the inflammatory microenvironment of the hair follicle, which plays a crucial part in the progression of alopecia areata.