Low-concentration vemurafenib induces the proliferation and invasion of human HaCaT keratinocytes through mitogen-activated protein kinase pathway activation

Author:

Roh Mi Ryung12,Kim Jung Min3,Lee Sang Hee1,Jang Hong Sun1,Park Kyu Hyun3,Chung Kee Yang1,Rha Sun Young345

Affiliation:

1. Department of Dermatology; Cutaneous Biology Research Institute; Yonsei University College of Medicine; Seoul Korea

2. Department of Dermatology; Wellman Center for Photomedicine; Massachusetts General Hospital; Harvard Medical School; Boston Massachusetts USA

3. Songdam Institute for Cancer Research; Yonsei University College of Medicine; Seoul Korea

4. Department of International Medicine; Yonsei University College of Medicine; Seoul Korea

5. Division of Medical Oncology; Yonsei University College of Medicine; Seoul Korea

Funder

Basic Science Research Program through the National Research Foundation of Korea, which is funded by the Ministry of Education, Science, and Technology

the Public Welfare & Safety Research Program through the National Research Foundation of Korea (NRF), which is funded by the Ministry of Education, Science, and Technology

Publisher

Wiley

Subject

Dermatology,General Medicine

Reference35 articles.

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2. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF;Wan;Cell,2004

3. Improved survival with vemurafenib in melanoma with BRAF V600E mutation;Chapman;N Engl J Med,2011

4. Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib;Sosman;N Engl J Med,2012

5. Inhibition of mutated, activated BRAF in metastatic melanoma;Flaherty;N Engl J Med,2010

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