1. Clinical Pharmacology Center Oita University Hospital Oita Japan
2. Department of Medical Ethics, Faculty of Medicine Oita University Oita Japan
3. Department of Clinical Pharmacology and Therapeutics, Faculty of Medicine Oita University Oita Japan
4. Department of Anatomy, Faculty of Medicine Oita University Oita Japan
5. Pharmaceutical Development Laboratory, Kyoto R&D Center Maruho Co., Ltd. Osaka Japan