Effect of the gut microbiota on the expression of genes that are important for maintaining skin function: Analysis using aged mice

Author:

Tabata Keito1,Ikarashi Nobutomo1ORCID,Shinozaki Yui1,Yoshida Ryotaro1,Kon Risako1,Sakai Hiroyasu1,Hosoe Tomoo1,Kamei Junzo2

Affiliation:

1. Department of Biomolecular Pharmacology Hoshi University Tokyo Japan

2. Juntendo Advanced Research Institute for Health Science Juntendo University Tokyo Japan

Abstract

AbstractThe gut microbiota changes greatly at the onset of disease, and the importance of intestinal bacteria has been highlighted. The gut microbiota also changes greatly with aging. Aging causes skin dryness, but it is not known how changes in the gut microbiota with aging affects the expression of genes that are important for maintaining skin function. In this study, we investigated how age‐related changes in gut microbiota affect the expression of genes that regulate skin function. The gut microbiotas from young mice and aged mice were transplanted into germ‐free mice (fecal microbiota transplantation [FMT]). These recipient mice were designated FMT‐young mice and FMT‐old mice respectively, and the expression levels of genes important for maintaining skin function were analyzed. The dermal water content was significantly lower in old mice than that in young mice, indicating dry skin. The gut microbiota significantly differed between old mice and young mice. The water channel aquaporin‐3 (Aqp3) expression level in the skin of FMT‐old mice was significantly higher than that in FMT‐young mice. In addition, among the genes that play an important role in maintaining skin function, the expression levels of those encoding ceramide‐degrading enzyme, ceramide synthase, hyaluronic acid‐degrading enzyme, and Type I collagen were also significantly higher in FMT‐old mice than in FMT‐young mice. It was revealed that the gut microbiota, which changes with age, regulates the expression levels of genes related to skin function, including AQP3.

Funder

Japan Society for the Promotion of Science

Publisher

Wiley

Subject

Dermatology,General Medicine

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Recent advances in exploring the properties and applications of hyaluronan;Journal of Dermatologic Science and Cosmetic Technology;2024-08

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3