Hyperhidrosis: A targeted literature review of the disease burden

Author:

Oshima Yuichiro1,Fujimoto Tomoko2ORCID,Nomoto Mariko3,Fukui Junko4,Ikoma Akihiko4

Affiliation:

1. Department of Dermatology Aichi Medical University School of Medicine Aichi Japan

2. Ikebukuro Nishiguchi Fukurou Dermatology Clinic Tokyo Japan

3. Creativ‐Ceutical Tokyo Japan

4. Maruho Co., Ltd. Osaka Japan

Abstract

AbstractHyperhidrosis is a chronic skin condition characterized by excessive sweating. It poses a burden on affected people, reducing their quality of life and productivity. We undertook a targeted literature review (TLR) to gather current evidence on the epidemiology as well as the human and economic burden posed on patients with hyperhidrosis. Searches were performed in Medline database (access via OVID interface) and ICHUSHI database. Articles published between January 2000 and September 2020 that analyzed at least 50 patients were included. Sixty‐four publications were identified and 38 publications covering a unique domain were selected to inform this TLR. The incidence of hyperhidrosis ranged from 0.13% in the UK to 0.28% in the USA, with a higher rate in females. The prevalence of hyperhidrosis varied from 2.8%–4.8% in the US general population to 18.40% in Chinese inpatients, while the prevalence of axillary hyperhidrosis varied from 1.4% in the US general population to 5.75% in Japanese employees/students. Due to excessive sweating, hyperhidrosis was reported to be a moderate‐to‐extreme limitation at work for the US patients, with 33.5% feeling unhappy. Patients' satisfaction was high post‐treatment. Considerable costs were related to the treatment with botulinum toxin and surgery. Hospital stays for surgery lasted from 10 h to 3 days. The percentage of patients who sought a medical consultation varied from 6.3% for Japanese patients with primary focal hyperhidrosis to 51% for the US general population with any type of hyperhidrosis. There is limited evidence of the hyperhidrosis burden, particularly among Japanese patients; however, the burden was high and limited patients' daily functioning. Future actions should include implementation of educational programs to raise awareness of the condition, conduct of larger studies, and generation of more evidence. Understanding the nature of hyperhidrosis and the burden it poses is of utmost importance.

Publisher

Wiley

Subject

Dermatology,General Medicine

Reference48 articles.

1. Pathophysiology and Treatment of Hyperhidrosis

2. Hyperhidrosis: prevalence and impact on quality of life

3. Hyperhidrosis: management options;McConaghy JRFD;Am Fam Physician,2018

4. Hyperhidrosis—causes and treatment of enhanced sweating. Deutsches Ärzteblatt;Tanja Schlereth MD;Dermatol Int,2009

5. Guidelines for the treatment of primary focal hyperhidrosis: a revised version 2015;Association JD;J Jpn Dermatol Assoc,2015

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