Effect of complicated, untreated and uncontrolled diabetes and pre‐diabetes on treatment outcome among patients with pulmonary tuberculosis-Reference-Cited by-同舟云学术

Effect of complicated, untreated and uncontrolled diabetes and pre‐diabetes on treatment outcome among patients with pulmonary tuberculosis

Published:2024-03-27 Issue:7 Volume:29 Page:624-632
ISSN:1323-7799
Container-title:Respirology
language:en
Short-container-title:Respirology

Author:

Kim Kyung Hoon¹,Kim Hyung Woo¹^ORCID,Kim Yong Hyun²^ORCID,Park Yeonhee³,Jung Sung Soo⁴,Kim Jin Woo⁵,Oh Jee Youn⁶^ORCID,Lee Heayon⁷,Kim Sung Kyoung⁸,Kim Sun‐Hyung⁹^ORCID,Lyu Jiwon¹⁰,Ko Yousang¹¹^ORCID,Kwon Sun Jung¹²,Jeong Yun‐Jeong¹³^ORCID,Kim Do Jin¹⁴,Koo Hyeon‐Kyoung¹⁵,Jegal Yangjin¹⁶,Kyung Sun Young¹⁷,Lee Sung Soon¹⁵,Park Jae Seuk¹⁸,Kim Ju Sang¹,Min Jinsoo¹⁹^ORCID

Affiliation:

1. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine The Catholic University of Korea Seoul Republic of Korea

2. Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Bucheon St. Mary's Hospital, College of Medicine The Catholic University of Korea Seoul Republic of Korea

3. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Daejeon St. Mary's Hospital, College of Medicine The Catholic University of Korea Seoul Republic of Korea

4. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine Chungnam National University Hospital Daejeon Republic of Korea

5. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine The Catholic University of Korea Seoul Republic of Korea

6. Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital Korea University College of Medicine Seoul Republic of Korea

7. Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine The Catholic University of Korea Seoul Republic of Korea

8. Division of Pulmonology, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine The Catholic University of Korea Seoul Republic of Korea

9. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine Chungbuk National University Hospital Cheongju Republic of Korea

10. Department of Pulmonary and Critical Care Medicine, Soonchunhyang University Cheonan Hospital Soonchunhyang University College of Medicine Cheonan Republic of Korea

11. Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Kangdong Sacred Heart Hospital Hallym University College of Medicine Seoul Republic of Korea

12. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Konyang University Hospital Konyang University College of Medicine Daejeon Korea

13. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine Dongguk University Ilsan Hospital Goyang Republic of Korea

14. Division of Allergy and Respiratory Medicine, Soonchunhyang University Bucheon Hospital Soonchunhyang University College of Medicine Bucheon Republic of Korea

15. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ilsan Paik Hospital Inje University College of Medicine Goyang Republic of Korea

16. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ulsan University Hospital Ulsan University College of Medicine Ulsan Republic of Korea

17. Division of Pulmonology, Department of Internal Medicine Gachon University Gil Hospital Incheon Republic of Korea

18. Division of Pulmonology, Department of Internal Medicine Dankook University College of Medicine Cheonan Republic of Korea

19. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine The Catholic University of Korea Seoul Republic of Korea

Abstract

AbstractBackground and ObjectivePatients with tuberculosis and diabetes have a higher risk of unfavourable anti‐tuberculosis treatment outcomes. In the present study, we aimed to evaluate the effects of various diabetes statuses on the outcomes of patients with pulmonary tuberculosis.MethodsAmong the patients with pulmonary tuberculosis enrolled in the Korea Tuberculosis Cohort (KTBC) registry and the multicentre prospective cohort study of pulmonary tuberculosis (COSMOTB), those with diabetes and complicated diabetes were identified. The primary and secondary outcomes were unfavourable outcomes and mortality, respectively. The effect of diabetes and complicated diabetes on the outcomes was assessed using multivariable logistic regression analysis. Using COSMOTB, subgroup analyses were performed to assess the association between various diabetes statuses and outcomes.ResultsIn the KTBC, diabetes (adjusted odds ratio [aOR] = 1.93, 95% CI = 1.64–2.26) and complicated diabetes (aOR = 1.96, 95% CI = 1.67–2.30) were significantly associated with unfavourable outcomes, consistent with the COSMOTB data analysis. Based on subgroup analysis, untreated diabetes at baseline was an independent risk factor for unfavourable outcomes (aOR = 2.72, 95% CI = 1.26–5.61). Prediabetes and uncontrolled diabetes increased unfavourable outcomes and mortality without statistical significance.ConclusionUntreated and complicated diabetes at the time of tuberculosis diagnosis increases the risk of unfavourable outcomes and mortality.

Funder

Korea National Institute of Health

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/resp.14714

Reference19 articles.

1. Global prevalence of diabetes in active tuberculosis: a systematic review and meta-analysis of data from 2·3 million patients with tuberculosis

2. International Diabetes Federation.IDF diabetes atlas. International Diabetes Federation (9th ed). [accessed 2023 Dec 11]. Retrieved fromhttp://www.idforg/about-diabetes/facts-figures

3. Diabetes and tuberculosis co-epidemic: the Bali Declaration

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