Patient‐centered digital biomarkers for allergic respiratory diseases and asthma: The <scp>ARIA‐EAACI</scp> approach – ARIA‐EAACI Task Force Report-Reference-Cited by-同舟云学术

Patient‐centered digital biomarkers for allergic respiratory diseases and asthma: The ARIA‐EAACI approach – ARIA‐EAACI Task Force Report

Published:2023-06-30 Issue:7 Volume:78 Page:1758-1776
ISSN:0105-4538
Container-title:Allergy
language:en
Short-container-title:Allergy

Author:

Bousquet Jean¹²³^ORCID,Shamji Mohamed H.⁴⁵^ORCID,Anto Josep M.⁶⁷⁸,Schünemann Holger J.⁹,Canonica G. Walter¹⁰¹¹,Jutel Marek¹²¹³,Del Giacco Stefano¹⁴^ORCID,Zuberbier Torsten¹³^ORCID,Pfaar Oliver¹⁵^ORCID,Fonseca Joao A.¹⁶¹⁷,Sousa‐Pinto Bernardo¹⁶¹⁷,Klimek Ludger¹⁸¹⁹^ORCID,Czarlewski Wienczyslawa²⁰²¹,Bedbrook Anna²¹²²,Amaral Rita¹⁶¹⁷^ORCID,Ansotegui Ignacio J.²³,Bosnic‐Anticevich Sinthia²⁴²⁵²⁶,Braido Fulvio²⁷²⁸,Chaves Loureiro Claudia²⁹^ORCID,Gemicioglu Bilun³⁰,Haahtela Tari³¹^ORCID,Kulus Marek³²,Kuna Piotr³³,Kupczyk Maciej³³,Matricardi Paolo M.³⁴^ORCID,Regateiro Frederico S.³⁵³⁶³⁷,Samolinski Boleslaw³⁸,Sofiev Mikhail³⁹,Toppila‐Salmi Sanna³¹^ORCID,Valiulis Arunas⁴⁰,Ventura Maria Teresa⁴¹⁴²,Barbara Cristina⁴³,Bergmann Karl C.¹³,Bewick Michael⁴⁴,Blain Hubert⁴⁵,Bonini Matteo⁴⁴⁶⁴⁷^ORCID,Boulet Louis‐Philippe⁴⁸^ORCID,Bourret Rodolphe⁴⁹,Brusselle Guy⁵⁰,Brussino Luisa⁵¹⁵²,Buhl Roland⁵³,Cardona Victoria⁵⁴⁵⁵,Casale Thomas⁵⁶,Cecchi Lorenzo⁵⁷^ORCID,Charpin Denis⁵⁸,Cherrez‐Ojeda Ivan⁵⁹⁶⁰^ORCID,Chu Derek K.⁹,Cingi Cemal⁶¹^ORCID,Costa Elisio M.⁶²,Cruz Alvaro A.⁶³^ORCID,Devillier Philippe⁶⁴,Dramburg Stephanie⁶⁵,Fokkens Wytske J.⁶⁶^ORCID,Gotua Maia⁶⁷,Heffler Enrico¹⁰¹¹^ORCID,Ispayeva Zhanat⁶⁸,Ivancevich Juan Carlos⁶⁹,Joos Guy⁵⁰,Kaidashev Igor⁷⁰,Kraxner Helga⁷¹,Kvedariene Violeta⁷²⁷³,Larenas‐Linnemann Désirée E.⁷⁴^ORCID,Laune Daniel⁷⁵,Lourenço Olga⁷⁶^ORCID,Louis Renaud⁷⁷⁷⁸,Makela Mika³¹,Makris Michael⁷⁹,Maurer Marcus¹³^ORCID,Melén Erik⁸⁰⁸¹,Micheli Yann⁷⁵,Morais‐Almeida Mario⁸²^ORCID,Mullol Joaquim⁸³⁸⁴,Niedoszytko Marek⁸⁵^ORCID,O'Hehir Robyn⁸⁶^ORCID,Okamoto Yoshitaka⁸⁷⁸⁸,Olze Heidi⁸⁹⁹⁰,Papadopoulos Nikolaos G.⁹¹^ORCID,Papi Alberto⁹²^ORCID,Patella Vincenzo⁹³⁹⁴⁹⁵^ORCID,Pétré Benoit⁹⁶,Pham‐Thi Nhân⁹⁷⁹⁸⁹⁹,Puggioni Francesca¹⁰⁰,Quirce Santiago¹⁰¹,Roche Nicolas¹⁰²,Rouadi Philip W.¹⁰³¹⁰⁴^ORCID,Sá‐Sousa Ana¹⁶¹⁷,Sagara Hironori¹⁰⁵,Sastre Joaquin¹⁰⁶,Scichilone Nicola¹⁰⁷,Sheikh Aziz¹⁰⁸,Sova Milan¹⁰⁹,Suppli Ulrik Charlotte¹¹⁰¹¹¹,Taborda‐Barata Luis¹¹²¹¹³,Todo‐Bom Ana¹¹⁴,Torres Maria J.¹¹⁵^ORCID,Tsiligianni Ioanna¹¹⁶¹¹⁷,Usmani Omar S.⁴¹¹⁸,Valovirta Erkka¹¹⁹,Vasankari Tuula¹²⁰¹²¹,Vieira Rafael José¹⁶¹⁷^ORCID,Wallace Dana¹²²,Waserman Susan¹²³,Zidarn Mihaela¹²⁴¹²⁵,Yorgancioglu Arzu¹²⁶^ORCID,Zhang Luo¹²⁷^ORCID,Chivato Tomas¹²⁸,Ollert Markus¹²⁹¹³⁰^ORCID

Affiliation:

1. Institute of Allergology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany

2. University Hospital Montpellier Montpellier France

3. Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology Berlin Germany

4. National Heart and Lung Institute (NHLI), Imperial College London London UK

5. NIHR Imperial Biomedical Research Centre London UK

6. ISGlobal, Barcelona Institute for Global Health Barcelona Spain

7. Universitat Pompeu Fabra (UPF) Barcelona Spain

8. CIBER Epidemiología y Salud Pública (CIBERESP) Barcelona Spain

9. Department of Health Research Methods, Evidence, and Impact, Department of Medicine McMaster University Hamilton Ontario Canada

10. Department of Biomedical Sciences Humanitas University Milan Italy

11. Personalized Medicine, Asthma & Allergy IRCCS Humanitas Research Center Milan Italy

12. Department of Clinical Immunology Wrocław Medical University Wroclaw Poland

13. ALL‐MED Medical Research Institute Wroclaw Poland

14. Department of Medical Sciences and Public Health and Unit of Allergy and Clinical Immunology University Hospital "Duilio Casula," University of Cagliari Cagliari Italy

15. Section of Rhinology and Allergy, Department of Otorhinolaryngology, Head and Neck Surgery University Hospital Marburg, Philipps‐Universität Marburg Marburg Germany

16. MEDCIDS ‐ Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine University of Porto Porto Portugal

17. CINTESIS@RISE– Health Research Network, Faculty of Medicine University of Porto Porto Portugal

18. Department of Otolaryngology, Head and Neck Surgery Universitätsmedizin Mainz Mainz Germany

19. Center for Rhinology and Allergology Wiesbaden Germany

20. Medical Consulting Czarlewski Levallois France

21. MASK‐air Montpellier France

22. ARIA Montpellier France

23. Department of Allergy and Immunology Hospital Quironsalud Bizkaia Bilbao Spain

24. Quality Use of Respiratory Medicines Group Woolcock Institute of Medical Research Sydney New South Wales Australia

25. Sydney Local Health District Sydney New South Wales Australia

26. Sydney Pharmacy School The University of Sydney Sydney New South Wales Australia

27. Respiratory Clinic, Department of Internal Medicine University of Genoa Genoa Italy

28. IRCCS Ospedale Policlinico San Martino Genoa Italy

29. Pneumology Unit Hospitais da Universidade de Coimbra, Centro Hospitalar e Universitário de Coimbra Coimbra Portugal

30. Department of Pulmonary Diseases Istanbul University ‐ Cerrahpaşa, Cerrahpaşa Faculty of Medicine Istanbul Turkey

31. Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki Helsinki Finland

32. Department of Pediatric Respiratory Diseases and Allergology Medical University of Warsaw Warsaw Poland

33. Division of Internal Medicine, Asthma and Allergy Barlicki University Hospital, Medical University of Lodz Lodz Poland

34. Pediatric Pulmonology, Immunology and Intensive Care Medicine Charité Universitätsmedizin Berlin Berlin Germany

35. Allergy and Clinical Immunology Unit Centro Hospitalar e Universitário de Coimbra Coimbra Portugal

36. Faculty of Medicine Coimbra Institute for Clinical and Biomedical Research (ICBR), University of Coimbra Coimbra Portugal

37. Faculty of Medicine Institute of Immunology, University of Coimbra Coimbra Portugal

38. Department of Prevention of Environmental Hazards, Allergology and Immunology Medical University of Warsaw Warsaw Poland

39. Finnish Meteorological Institute (FMI) Helsinki Finland

40. Institute of Clinical Medicine and Institute of Health Sciences, Medical Faculty of Vilnius University Vilnius Lithuania

41. Unit of Geriatric Immunoallergology University of Bari Medical School Bari Italy

42. Institute of Sciences of Food Production, National Research Council (Ispa‐CNR) Bari Italy

43. Portuguese National Programme for Respiratory Diseases, Direção ‐Geral da Saúde, Faculdade de Medicina de Lisboa Instituto de Saúde Ambiental Lisbon Portugal

44. University of Central Lancashire Medical School Preston UK

45. Department of Geriatrics Montpellier University Hospital, MUSE Montpellier France

46. Department of Cardiovascular and Respiratory Sciences Universita Cattolica del Sacro Cuore Rome Italy

47. Department of Neurological, ENT and Thoracic Sciences Fondazione Policlinico Universitario A Gemelli ‐ IRCCS Rome Italy

48. Quebec Heart and Lung Institute, Laval University Quebec City Quebec Canada

49. University Hospital of Nice Nice France

50. Department of Respiratory Medicine Ghent University Hospital Ghent Belgium

51. Department of Medical Sciences University of Torino Torino Italy

52. Allergy and Clinical Immunology Unit Mauriziano Hospital Torino Italy

53. Department of Pulmonary Medicine Mainz University Hospital Mainz Germany

54. Allergy Section, Department of Internal Medicine Hospital Vall d'Hebron Barcelona Spain

55. ARADyAL Research Network Barcelona Spain

56. Division of Allergy/Immunology University of South Florida Tampa Florida USA

57. SOS Allergology and Clinical Immunology, USL Toscana Centro Prato Italy

58. Clinique des Bronches, Allergie et Sommeil, Hôpital Nord Marseille France

59. Universidad Espíritu Santo Samborondón Ecuador

60. Respiralab Research Group Guayas Ecuador

61. ENT Department, Medical Faculty Eskisehir Osmangazi University Eskisehir Turkey

62. UCIBIO, REQUINTE, Faculty of Pharmacy and Competence Center on Active and Healthy Ageing University of Porto (Porto4Ageing) Porto Portugal

63. Fundaçao ProAR, Federal University of Bahia and GARD/WHO Planning Group Salvador Brazil

64. VIM Suresnes, UMR 0892, Pôle des Maladies des Voies Respiratoires, Hôpital Foch, Université Paris‐Saclay Suresnes France

65. Department of Pediatric Pneumology, Immunology and Intensive Care Medicine Charité Medical University Berlin Germany

66. Department of Otorhinolaryngology Amsterdam University Medical Centres Amsterdam The Netherlands

67. Center of Allergy and Immunology David Tvildiani Medical University Tbilisi Georgia

68. Kazakhstan Association of Allergology and Clinical Immunology, Department of Allergology and Clinical Immunology of the Kazakh National Medical University Almaty Kazakhstan

69. Servicio de Alergia e Immunologia, Clinica Santa Isabel Buenos Aires Argentina

70. Poltava State Medical University Poltava Ukraine

71. Department of Otorhinolaryngology, Head and Neck Surgery Semmelweis University Budapest Hungary

72. Faculty of Medicine Institute of Clinical Medicine, Clinic of Chest Diseases and Allergology, Vilnius University Vilnius Lithuania

73. Department of Pathology, Faculty of Medicine Institute of Biomedical Sciences, Vilnius University Vilnius Lithuania

74. Center of Excellence in Asthma and Allergy Médica Sur Clinical Foundation and Hospital México City Mexico

75. KYomed INNOV Montpellier France

76. Faculty of Health Sciences and CICS – UBI, Health Sciences Research Centre University of Beira Interior Covilhã Portugal

77. Department of Pulmonary Medicine CHU Liège Liège Belgium

78. GIGA I3 Research Group University of Liège Liège Belgium

79. Allergy Unit "D Kalogeromitros," 2nd Department of Dermatology and Venereology National & Kapodistrian University of Athens, "Attikon" University Hospital Athens Greece

80. Department of Clinical Science and Education, Södersjukhuset Karolinska Institutet Stockholm Sweden

81. Sach's Children and Youth Hospital Stockholm Sweden

82. Allergy Center CUF Descobertas Hospital Lisbon Portugal

83. Rhinology Unit & Smell Clinic, ENT Department Hospital Clínic Barcelona Spain

84. Clinical & Experimental Respiratory Immunoallergy IDIBAPS, CIBERES, University of Barcelona Barcelona Spain

85. Department of Allergology Medical University of Gdansk Gdansk Poland

86. Allergy, Asthma and Clinical Immunology, Alfred Health and Department of Immunology, Central Clinical School Monash University Melbourne Victoria Australia

87. Chiba Rosai Hospital Chiba Japan

88. Chiba University Hospital Chiba Japan

89. Department of Otorhinolaryngology Charité‐Universitätsmedizin Berlin Berlin Germany

90. Berlin Institute of Health Berlin Germany

91. Allergy Department, 2nd Pediatric Clinic University of Athens Athens Greece

92. Respiratory Medicine, Department of Translational Medicine University of Ferrara Ferrara Italy

93. Division of Allergy and Clinical Immunology, Department of Medicine "Santa Maria della Speranza" Hospital, Battipaglia Salerno Italy

94. Agency of Health ASL Salerno Italy

95. Postgraduate Programme in Allergy and Clinical Immunology University of Naples Federico II Naples Italy

96. Department of Public Health University of Liège Liège Belgium

97. Ecole Polytechnique de Palaiseau Palaiseau France

98. IRBA (Institut de Recherche Bio‐Médicale des Armées) Brétigny sur Orge France

99. Université Paris Cité Paris France

100. Personalized Medicine, Asthma & Allergy Humanitas Clinical and Research Center IRCCS, Rozzano Milan Italy

101. Department of Allergy Hospital La Paz Institute for Health Research (IdiPAZ) Madrid Spain

102. Pneumologie AP‐HP Centre Université de Paris Cité, Hôpital Cochin, et UMR 1016, Institut Cochin Paris France

103. Department of Otolaryngology, Head and Neck Surgery, Eye and Ear University Hospital Beirut Lebanon

104. Department of Otolaryngology, Head and Neck Surgery Dar Al Shifa Hospital ‐ Salmiya Hawally Kuwait

105. Department of Medicine, Division of Respiratory Medicine and Allergology Showa University School of Medicine Tokyo Japan

106. Allergy Service, Fundacion Jimenez Diaz Autonoma University of Madrid, CIBERES‐ISCIII Madrid Spain

107. PROMISE Department University of Palermo Palermo Italy

108. Usher Institute, The University of Edinburgh Edinburgh UK

109. Department of Respiratory Medicine and Tuberculosis University Hospital Brno Lískovec Czech Republic

110. Department of Respiratory Medicine Copenhagen University Hospital‐Hvidovre Copenhagen Denmark

111. Institute of Clinical Medicine, University of Copenhagen Copenhagen Denmark

112. Department of Immunoallergology Cova da Beira University Hospital Centre Covilhã Portugal

113. UBIAir ‐ Clinical & Experimental Lung Centre and CICS‐UBI Health Sciences Research Centre University of Beira Interior Covilhã Portugal

114. Imunoalergologia, Faculty of Medicine Centro Hospitalar Universitário de Coimbra, University of Coimbra Coimbra Portugal

115. Allergy Unit Málaga Regional University Hospital‐IBIMA Málaga Spain

116. International Primary Care Respiratory Group (IPCRG) Aberdeen UK

117. Health Planning Unit, Department of Social Medicine, Faculty of Medicine University of Crete Heraklion Greece

118. Royal Brompton Hospital, Airways Disease Section London UK

119. Department of Lung Diseases and Clinical Immunology University of Turku Turku Finland

120. FIHLA, Finnish Lung Health Association Helsinki Finland

121. Department of Clinical Medicine, Pulmonary Diseases and Clinical Allergology University of Turku Turku Finland

122. Nova Southeastern University, College of Allopathic Medicine Fort Lauderdale Florida USA

123. Department of Medicine, Clinical Immunology and Allergy McMaster University Hamilton Ontario Canada

124. University Clinic of Respiratory and Allergic Diseases Golnik Slovenia

125. Faculty of Medicine University of Ljubljana Ljubljana Slovenia

126. Department of Pulmonary Diseases, Faculty of Medicine Celal Bayar University Manisa Turkey

127. Department of Otolaryngology Head and Neck Surgery Beijing TongRen Hospital and Beijing Institute of Otolaryngology Beijing China

128. School of Medicine University CEU San Pablo Madrid Spain

129. Department of Infection and Immunity Luxembourg Institute of Health Esch‐sur‐Alzette Luxembourg

130. Department of Dermatology and Allergy Centre Odense University Hospital, Odense Research Center for Anaphylaxis (ORCA) Odense Denmark

Abstract

AbstractBiomarkers for the diagnosis, treatment and follow‐up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the center of the health system and is likely to optimize the practice of allergy. Allergic Rhinitis and its Impact on Asthma (ARIA) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient‐reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomized controlled trials, observational real‐life studies and allergen challenges. Using the MASK‐air app as a model, a daily electronic combined symptom‐medication score for allergic diseases (CSMS) or for asthma (e‐DASTHMA), combined with a monthly control questionnaire, was embedded in a strategy similar to the diabetes approach for disease control. To mimic real‐life, it secondly proposed quality‐of‐life digital biomarkers including daily EQ‐5D visual analogue scales and the bi‐weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed.

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/all.15740

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