Phenotypical analysis of ectoenzymes CD39/CD73 and adenosine receptor 2A in CD4+CD25highFoxp3+regulatory T-cells in psoriasis

Author:

Han Ling12,Sugiyama Hideaki23,Zhang Qi1,Yan Kexiang1,Fang Xu1,McCormick Thomas S2,Cooper Kevin D24,Huang Qiong1

Affiliation:

1. Department of Dermatology; Huashan Hospital; Shanghai China

2. Department of Dermatology; Case Western Reserve University; Cleveland Ohio USA

3. Department of Dermatology; Seirei Yokohama General Hospital; Yokohama Japan

4. The Murdough Family Center for Psoriasis; University Hospital Case Medical Center; Cleveland Ohio USA

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Publisher

Wiley

Subject

Dermatology

Reference28 articles.

1. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases;Sakaguchi;J. Immunol.,1995

2. Regulatory T cells under scrutiny;Bach;Nat. Rev. Immunol.,2003

3. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self;Sakaguchi;Nat. Immunol.,2005

4. Human CD4+CD25 (high) CD127 (low/neg) regulatory T cells;Su;Methods Mol. Biol.,2012

5. Adenosine generation catalyzed by CD39 and C D73 expressed on regulatory T cells mediates immune suppression;Deaglio;J. Exp. Med.,2007

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