Histiocytoid melanoma: Diagnostic pitfall and mimicker of non‐Langerhans cell histiocytoses including reticulohistiocytoma

Author:

Grand David G.1,Barton Dorothea T.1,Yan Shaofeng2ORCID,Sriharan Aravindhan2,Momtahen Shabnam2ORCID,Cloutier Jeffrey M.2,LeBlanc Robert E.2ORCID

Affiliation:

1. Department of Dermatology Geisel School of Medicine, Dartmouth‐Hitchcock Medical Center Lebanon New Hampshire USA

2. Department of Pathology and Laboratory Medicine Geisel School of Medicine, Dartmouth‐Hitchcock Medical Center Lebanon New Hampshire USA

Abstract

AbstractMelanoma and benign histiocytic proliferations can sometimes show considerable clinical and histopathologic overlap. Recently, cases of melanomas resembling xanthogranuloma and Rosai–Dorfman disease have been reported, and herein we report a case of melanoma closely mimicking reticulohistiocytoma. An 84‐year‐old man presented with a 1 cm purple‐red nodule on his arm concerning for squamous cell carcinoma. While the biopsy findings resembled reticulohistiocytoma, the clinical context and regression changes at the lesion perimeter raised stronger concern for melanoma, which was confirmed with immunohistochemistry. We review prior rare reports of melanomas resembling non‐Langerhans cell histiocytic proliferations and summarize helpful clinical and histopathologic clues to avoid a diagnostic pitfall when confronted with this unusual quandary.

Publisher

Wiley

Subject

Dermatology,Histology,Pathology and Forensic Medicine

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