Maternal periodontal diseases affect the leukocyte profiles of umbilical cord blood: A cohort study

Author:

Zhao Dan12ORCID,Cheng Tianfan2,Hu Dangli3ORCID,Xu Xiaoyi4,Zhang Feng5,Yu Rong4,Li Huijun5,Wen Ping4,Chen Lihua6,Fu Mali6,Yang Hong6,Zhang Hanyu6,Yao Jilong3,Jin Lijian2ORCID

Affiliation:

1. Department of Implant Dentistry, Beijing Stomatological Hospital Capital Medical University Beijing China

2. Division of Periodontology & Implant Dentistry, Faculty of Dentistry The University of Hong Kong Hong Kong China

3. Division of Obstetrics & Gynecology, Shenzhen Maternity & Child Healthcare Hospital The First School of Clinical Medicine, Southern Medical University Shenzhen China

4. Division of Science & Education Shenzhen Maternity & Child Healthcare Hospital Shenzhen China

5. Division of Stomatology Shenzhen Maternity & Child Healthcare Hospital Shenzhen China

6. Division of Obstetrics & Gynecology Shenzhen Maternity & Child Healthcare Hospital Shenzhen China

Abstract

AbstractAimThis study evaluated the connection of periodontal status with the leukocyte profiles of maternal peripheral blood (MPB) and umbilical cord blood (UCB).Materials and MethodsNinety‐nine pregnant females were recruited, and their data were collected via questionnaire and from medical records, including demographics, systemic conditions, complete blood count (CBC) and C‐reaction protein (CRP) level in MPB. Full‐mouth periodontal assessment was performed. CBC and CRP levels in UCB were measured after parturition.ResultsAll subjects and their neonates were generally healthy. 30.3% of the participants presented with periodontal health condition, whereas 69.7% had different severities of periodontal diseases. The counts/percentages of eosinophils and monocytes in UCB from the subjects with periodontal diseases elevated, and the percentage of neutrophils decreased referencing to that from the counterparts (p < 0.05). There were positive correlations for total leukocyte count, neutrophils and lymphocytes counts/percentages in MPB and UCB among the periodontally healthy subjects (r > 0.4, p < 0.05), but such findings did not exist in those with periodontal diseases. Moreover, periodontal diseases independently accounted for the counts/percentages of neutrophils and eosinophils in UCB after controlling confounders in four testing models (ANCOVA, p < 0.05).ConclusionMaternal periodontal diseases could to some extent disturb the leukocyte profiles of umbilical cord blood.

Publisher

Wiley

Subject

General Dentistry,Otorhinolaryngology

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