Crosstalk among T cells, epithelial cells, and fibroblasts identifies a prognostic signature in oral squamous cell carcinoma

Author:

Jiang Zhishen1ORCID,Zhang Zijian1ORCID,You Xiaotong1,Ye Li12,Lin Weimin13,Liu Liu14ORCID,Cao Yubin12ORCID,Pan Jian12ORCID

Affiliation:

1. State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University Chengdu China

2. Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology Sichuan University Chengdu China

3. Department of Oral Implantology, West China Hospital of Stomatology Sichuan University Chengdu China

4. Department of Conservative Dentistry and Endodontics, West China Hospital of Stomatology Sichuan University Chengdu China

Abstract

AbstractObjectivesThis study aimed to analyze the crosstalk network among T cells, epithelial cells, and fibroblasts in the tumor microenvironment of oral squamous cell carcinoma (OSCC) and to determine their prognostic values.Materials and MethodsSingle‐cell subpopulation identification and communication analysis identified crosstalk markers. The least absolute shrinkage and selection operator Cox analysis identified key prognostic features by integrating the bulk transcriptome and clinical parameters. Functional analysis and immune infiltration were explored to determine possible mechanisms.ResultsInteractions between epithelial cells and fibroblasts primarily involve MIF, MK, PTN, IGF, EGF, and PERIOSTIN, whereas T cells interact with epithelial cells and fibroblasts through MIF, CXCL, PAR, IFN, and EGF signals. We constructed a novel prognostic feature comprising 13 crosstalk genes: HBEGF, FGF7, GRN, ITGB5, CXCR6, ERBB2, AREG, F2RL2, NAMPT, KLK12, HMGB2, TUBA1B, and KLRD1. Patients were stratified based on the RiskScore. Functional analysis revealed that the high‐risk group was enriched in immunosuppressive pathways (p < 0.001). Immune checkpoints including PD‐1, PD‐L1, and CTLA4 were more highly expressed in the high‐risk group (p < 0.05).ConclusionsThe crosstalk network among T cells, epithelial cells, and fibroblasts is complex and may have implications for prognosis and clinical treatments of OSCC patients.

Funder

Fundamental Research Funds for the Central Universities

Publisher

Wiley

Subject

General Dentistry,Otorhinolaryngology

Reference51 articles.

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