Chimeric antigen receptor and bispecific T‐cell engager therapies in multiple myeloma patients with prior allogeneic transplantation

Author:

Hammons Lindsay1,Haider Shabi1,Portuguese Andrew J.2ORCID,Banerjee Rahul2ORCID,Szabo Aniko1,Pasquini Marcelo1ORCID,Chhabra Saurabh3ORCID,Radhakrishnan Sabarinath1,Mohan Meera1ORCID,Narra Ravi1,Dong Jing1,Janz Siegfried1,Shah Nirav N.1ORCID,Hamadani Mehdi1ORCID,D'Souza Anita1ORCID,Hari Parameswaran1,Dhakal Binod1ORCID

Affiliation:

1. BMT and Cellular Therapy Program, Department of Medicine Medical College of Wisconsin Milwaukee Wisconsin USA

2. Clinical Research Division Fred Hutchinson Cancer Center Seattle Washington USA

3. Division of Hematology/Oncology, Department of Medicine Mayo Clinic Arizona Phoenix Arizona USA

Abstract

SummaryChimeric antigen receptor T‐cell (CAR‐T) therapy and bispecific T‐cell engagers (BsAb) have emerged as promising immunotherapeutic modalities in patients with relapsed and/or refractory multiple myeloma (RRMM). However, there is limited data on the safety and efficacy of CAR‐T and BsAb therapies in MM patients with a prior history of allogeneic transplantation (allo‐HCT). Thirty‐three MM patients with prior allo‐HCT received CAR‐T (n = 24) or BsAb (n = 9) therapy. CAR‐T therapy demonstrated an ORR of 92% (67% ≥ CR), and 73% were MRD negative. BsAb therapy resulted in an ORR of 44% (44% ≥ CR) and 44% MRD negative. Safety analysis showed grade ≥3 AEs in 92% of CAR‐T and 56% of BsAb patients. Cytokine release syndrome (CRS) occurred in 83% of CAR‐T and 78% of BsAb recipients, while immune effector cell‐associated neurotoxicity syndrome (ICANS) was observed in three CAR‐T patients. Infections of grade ≥3 were reported in 50% of CAR‐T and 44% of BsAb recipients. No exacerbation of graft‐versus‐host disease occurred except in one BsAb recipient. CAR‐T and BsAb therapies appear to be feasible, safe and provide deep and durable responses in MM patients with prior allo‐HCT.

Publisher

Wiley

Subject

Hematology

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