Long‐term sorbitol consumption affects the hippocampus and alters cognitive function in aged mice-Reference-Cited by-同舟云学术

Long‐term sorbitol consumption affects the hippocampus and alters cognitive function in aged mice

Published:2024-03-11 Issue:5 Volume:29 Page:432-437
ISSN:1356-9597
Container-title:Genes to Cells
language:en
Short-container-title:Genes to Cells

Author:

Yokoi Haruna¹²^ORCID,Wang Jingshu¹,Ikuyo Yoriko¹³,Yamada Mitsuyoshi¹⁴,Shikama Yosuke¹²,Furukawa Masae¹^ORCID,Matsushita Kenji¹²³

Affiliation:

1. Department of Oral Disease Research, Geroscience Research Center National Center for Geriatrics and Gerontology Obu Japan

2. Department of Geriatric Oral Science, Graduate School of Dentistry Tohoku University Sendai Japan

3. Section of Community Oral Health and Epidemiology, Division of Oral Health, Technology and Epidemiology, Faculty of Dental Science Kyushu University Fukuoka Japan

4. Department of Operative Dentistry, School of Dentistry Aichi Gakuin University Nagoya Japan

Abstract

AbstractThe systemic effects of the artificial sweetener sorbitol on older adult individuals have not been elucidated. We assessed the effects of sorbitol consumption on cognitive and gingival health in a mouse model. Aged mice were fed 5% sorbitol for 3 months before their behavior was assessed, and brain and gingival tissues were collected. Long‐term sorbitol consumption inhibited gingival tissue aging in aged mice. However, it caused cognitive decline and decreased brain‐derived neurotrophic factor (BDNF) in the hippocampus. Sorbitol consumption did not affect homeostatic function; however, it may exert effects within the brain, particularly in the hippocampus.

Funder

Japan Society for the Promotion of Science

National Center for Geriatrics and Gerontology

Hokuto Foundation for Bioscience

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/gtc.13112

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