Multi‐ancestry genome‐wide association study of asthma exacerbations

Author:

Herrera‐Luis Esther1ORCID,Ortega Victor E.2,Ampleford Elizabeth J.3,Sio Yang Yie4,Granell Raquel5ORCID,de Roos Emmely67,Terzikhan Natalie67,Vergara Ernesto Elorduy8,Hernandez‐Pacheco Natalia910ORCID,Perez‐Garcia Javier1ORCID,Martin‐Gonzalez Elena1,Lorenzo‐Diaz Fabian111ORCID,Hashimoto Simone12ORCID,Brinkman Paul12,Jorgensen Andrea L.13,Yan Qi14ORCID,Forno Erick15ORCID,Vijverberg Susanne J.161718ORCID,Lethem Ryan5,Espuela‐Ortiz Antonio1ORCID,Gorenjak Mario19ORCID,Eng Celeste20,González‐Pérez Ruperto2122,Hernández‐Pérez José M.2324ORCID,Poza‐Guedes Paloma2122ORCID,Sardón Olaia2526,Corcuera Paula25ORCID,Hawkins Greg A.27,Marsico Annalisa28,Bahmer Thomas2930,Rabe Klaus F.2930,Hansen Gesine31,Kopp Matthias Volkmar323334,Rios Raimon35,Cruz Maria Jesus1036,González‐Barcala Francisco‐Javier37,Olaguibel José María1038ORCID,Plaza Vicente1039ORCID,Quirce Santiago1040ORCID,Canino Glorisa41,Cloutier Michelle42ORCID,del Pozo Victoria1043ORCID,Rodriguez‐Santana Jose R.44,Korta‐Murua Javier26,Villar Jesús1045,Potočnik Uroš46,Figueiredo Camila47ORCID,Kabesch Michael48,Mukhopadhyay Somnath4950,Pirmohamed Munir51ORCID,Hawcutt Daniel B.525354ORCID,Melén Erik955ORCID,Palmer Colin N.50ORCID,Turner Steve56ORCID,Maitland‐van der Zee Anke H.161718ORCID,von Mutius Erika575859ORCID,Celedón Juan C.15ORCID,Brusselle Guy6760ORCID,Chew Fook Tim4ORCID,Bleecker Eugene61,Meyers Deborah61,Burchard Esteban G.2262ORCID,Pino‐Yanes Maria11063ORCID,

Affiliation:

1. Genomics and Health Group Department of Biochemistry, Microbiology, Cell Biology and Genetics Universidad de La Laguna (ULL) San Cristóbal de La Laguna, Tenerife Spain

2. Division of Respiratory Medicine Department of Internal Medicine Mayo Clinic Scottsdale Arizona USA

3. Department of Internal Medicine Center for Precision Medicine Wake Forest School of Medicine Winston‐Salem North Carolina USA

4. Department of Biological Sciences National University of Singapore Singapore City Singapore

5. MRC Integrative Epidemiology Unit (IEU) Population Health Sciences Bristol Medical School University of Bristol Bristol UK

6. Department of Epidemiology Erasmus University Medical Center Rotterdam The Netherlands

7. Department of Respiratory Medicine Ghent University Hospital Ghent Belgium

8. Institute of Computation Biology Helmholtz Zentrum München German Research Center for Environmental Health Munich Germany

9. Department of Clinical Sciences and Education Södersjukhuset Karolinska Institutet Stockholm Sweden

10. CIBER de Enfermedades Respiratorias (CIBERES) Madrid Spain

11. Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUETSPC) Universidad de La Laguna (ULL) San Cristóbal de La Laguna, Tenerife Spain

12. Department of Respiratory Medicine Amsterdam University Medical Center University of Amsterdam Amsterdam The Netherlands

13. Department of Health Data Science Institute of Population Health University of Liverpool Liverpool UK

14. Department of Obstetrics and Gynecology Columbia University Irving Medical Center New York New York USA

15. Division of Pediatric Pulmonary Medicine UPMC Children's Hospital of Pittsburgh University of Pittsburgh Pittsburgh Pennsylvania USA

16. Department of Respiratory Medicine Amsterdam UMC University of Amsterdam Amsterdam The Netherlands

17. Division of Pharmacoepidemiology and Clinical Pharmacology Faculty of Science Utrecht University Utrecht The Netherlands

18. Department of Paediatric Respiratory Medicine and Allergy Emma's Children Hospital Amsterdam UMC University of Amsterdam Amsterdam The Netherlands

19. Center for Human Molecular Genetics and Pharmacogenomics Faculty of Medicine University of Maribor Maribor Slovenia

20. Department of Medicine University of California San Francisco San Francisco California USA

21. Allergy Department Hospital Universitario de Canarias Santa Cruz de Tenerife Tenerife Spain

22. Severe Asthma Unit, Allergy Department Hospital Universitario de Canarias Santa Cruz de Tenerife Tenerife Spain

23. Pulmonary Medicine Hospital Universitario de N.S de Candelaria Santa Cruz de Tenerife Spain

24. Pulmonary Medicine Hospital General de La Palma La Palma, Santa Cruz de Tenerife Spain

25. Division of Pediatric Respiratory Medicine Hospital Universitario Donostia San Sebastián Spain

26. Department of Pediatrics University of the Basque Country (UPV/EHU) San Sebastián Spain

27. Department of Biochemistry Wake Forest School of Medicine Winston‐Salem North Carolina USA

28. Computational Health Center Helmholtz Zentrum München German Research Center for Environmental Health Munich Germany

29. LungenClinic Grosshansdorf, Pneumology Grosshansdorf Germany

30. Airway Research Center North (ARCN) Members of the Germany Center for Lung Research (DZL) Grosshansdorf Germany

31. Department of Pediatric Pneumology, Allergology and Neonatology Hannover Medical School Hannover Germany

32. Division of Pediatric Pneumology & Allergology University Medical Center Schleswig‐Holstein Lübeck Germany

33. Airway Research Center North (ARCN) Members of the Germany Center for Lung Research (DZL) Lübeck Germany

34. Department of Paediatric Respiratory Medicine Inselspital University Children's Hospital of Bern University of Bern Bern Switzerland

35. Programa de Pós Graduação em Imunologia (PPGIm) Instituto de Ciências da Saúde Universidade Federal da Bahia (UFBA) Salvador Brazil

36. Servicio de Neumología Hospital Vall d’Hebron Barcelona Spain

37. Servicio de Neumología Complejo Hospitalario Universitario de Santiago Santiago de Compostela Spain

38. Servicio de Alergología Complejo Hospitalario de Navarra Pamplona Navarra Spain

39. Departamento de Medicina Respiratoria Hospital de la Santa Creu i Sant Pau Instituto de Investigación Biomédica Sant Pau (IIB Sant Pau) Barcelona Spain

40. Department of Allergy La Paz University Hospital IdiPAZ Madrid Spain

41. Behavioral Sciences Research Institute University of Puerto Rico San Juan Puerto Rico

42. Department of Pediatrics University of Connecticut Farmington Connecticut USA

43. Immunology Department Instituto de Investigación Sanitaria Hospital Universitario Fundación Jiménez Díaz Madrid Spain

44. Centro de Neumología Pediátrica San Juan Puerto Rico

45. Multidisciplinary Organ Dysfunction Evaluation Research Network Research Unit Hospital Universitario Dr. Negrín Las Palmas de Gran Canaria Spain

46. Laboratory for Biochemistry, Molecular Biology and Genomics Faculty for Chemistry and Chemical Engineering University of Maribor Maribor Slovenia

47. Instituto de Ciências da Saúde Universidade Federal da Bahia Salvador Brazil

48. Department of Paediatric Pneumology and Allergy University Children's Hospital Regensburg (KUNO) Regensburg Germany

49. Academic Department of Paediatrics Brighton and Sussex Medical School, Royal Alexandra Children's Hospital Brighton UK

50. Population Pharmacogenetics Group Biomedical Research Institute Ninewells Hospital and Medical School University of Dundee Dundee UK

51. Department of Pharmacology and Therapeutics Institute of Systems, Molecular and Integrative Biology University of Liverpool Liverpool UK

52. Department of Women's and Children's Health University of Liverpool Liverpool UK

53. Alder Hey Children's Hospital Liverpool UK

54. NIHR Alder Hey Clinical Research Facility Alder Hey Children's Hospital Liverpool UK

55. Sachs’ Children’s Hospital South General Hospital Stockholm Sweden

56. Child Health University of Aberdeen Aberdeen UK

57. Institute for Asthma and Allergy Prevention Helmholtz Zentrum München German Research Center for Environmental Health Munich Germany

58. Dr von Hauner Children's Hospital Ludwig‐Maximilians‐Universität Munich Germany

59. Comprehensive Pneumology Center Munich (CPC‐M) Member of the German Center for Lung Research Munich Germany

60. Department of Respiratory Medicine Erasmus University Medical Center Rotterdam The Netherlands

61. Division of Genetics, Genomics, and Precision Medicine Department of Internal Medicine University of Arizona College of Medicine Tucson Arizona USA

62. Department of Bioengineering and Therapeutic Sciences University of California San Francisco San Francisco California USA

63. Instituto de Tecnologías Biomédicas (ITB) Universidad de La Laguna (ULL) San Cristóbal de La Laguna, Tenerife Spain

Funder

Instituto de Salud Carlos III

European Commission

Erasmus Medisch Centrum

European Regional Development Fund

University of Bristol

Universidad de La Laguna

UK Medical Research Council

Erasmus Universiteit Rotterdam

Slovenian Research Agency

National Human Genome Research Institute

Tobacco-Related Disease Research Program

National Institute of General Medical Sciences

European Respiratory Society

National Institute on Minority Health and Health Disparities

American Asthma Foundation

European Academy of Allergy and Clinical Immunology

European Union

European Social Fund

European Federation of Pharmaceutical Industries and Associations

Publisher

Wiley

Subject

Immunology,Immunology and Allergy,Pediatrics, Perinatology and Child Health

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