Structure-activity relationships of bumetanide derivatives: correlation between diuretic activity in dogs and inhibition of the human NKCC2A transporter

Author:

Lykke Kasper1,Töllner Kathrin23,Römermann Kerstin23,Feit Peter W2,Erker Thomas4,MacAulay Nanna1,Löscher Wolfgang23

Affiliation:

1. Department of Cellular and Molecular Medicine; University of Copenhagen; Copenhagen Denmark

2. Department of Pharmacology, Toxicology, and Pharmacy; University of Veterinary Medicine Hannover; Hannover Germany

3. Center for Systems Neuroscience; Hannover Germany

4. Department of Medicinal Chemistry; University of Vienna; Vienna Austria

Funder

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

Pharmacology

Reference58 articles.

1. The Concise Guide to PHARMACOLOGY 2013/14: Transporters;Alexander;Br J Pharmacol,2013

2. Blocking seizures with the diuretic bumetanide: promises and pitfalls;Ben Ari;Epilepsia,2012

3. Drug transport by Organic Anion Transporters (OATs);Burckhardt;Pharmacol Ther,2012

4. Localization and functional characterization of the human NKCC2 isoforms;Carota;Acta Physiol (Oxf),2010

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