Affiliation:
1. Centres for Virus Research and Cancer Research The Westmead Institute for Medical Research, Faculty of Medicine and Health, University of Sydney Westmead NSW Australia
Abstract
AbstractIn this article, we discuss a recently published article that demonstrated a novel way of identifying viral pathogens reactivating in human cells to be used as cellular therapy, in this instance chimeric antigen receptor (CAR) T cells. The authors used search engines and databases to identify viruses able to reactivate in T cells and then tested this initially in T‐cell cultures, specifically human herpesvirus 6. This virus was then shown to reactivate infrequently in vitro and in vivo in CAR T cells as a consequence of T‐cell activation. The methodology may be most clinically useful for more frequently reactivating viruses in other types of cellular therapy such as allogenic CAR T cells or induced pluripotent stem cells.
Subject
Cell Biology,Immunology,Immunology and Allergy