Bridging science and accessibility: a tactile journey from gluten through to coeliac disease

Author:

Henneken Lee M1,Loh Tiing Jen23,Ciacchi Laura23ORCID,Ciacchi Lisa23ORCID,Lim Jia‐Jia23,Reid Hugh H23,Tye‐Din Jason A14ORCID

Affiliation:

1. Department of Gastroenterology Royal Melbourne Hospital Parkville VIC Australia

2. Department of Biochemistry and Molecular Biology Monash University Clayton VIC Australia

3. Immunity Program Biomedicine Discovery Institute, Monash University Clayton VIC Australia

4. Immunology Division Walter and Eliza Hall Institute Parkville VIC Australia

Abstract

AbstractAs part of the Monash Sensory Science Exhibition, our team guided participants through a multisensory journey unraveling coeliac disease development and pathology. Through tactile and sensory exhibits, we showed how benign dietary gluten can be transformed into a harmful entity for the 1 in 70 Australians with this illness. In contrast to the common misconception of coeliac disease as a food allergy, our exhibits revealed its closer association with autoimmune diseases such as type 1 diabetes, involving genetic susceptibility linked to specific human leukocyte antigens, crucial antigen‐specific T‐ and B‐cell responses and autoantibody production. Tactile models underscored the severe consequences of the proinflammatory immune response to gluten on patient health and quality of life. This educational event affirmed to us the value and importance of fostering inclusivity in science education.

Publisher

Wiley

Subject

Cell Biology,Immunology,Immunology and Allergy

Reference16 articles.

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4. Evidence for a primary association of celiac disease to a particular HLA‐DQ alpha/beta heterodimer;Sollid LM;J Exp Med,1989

5. Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac disease;Tye‐Din JA;Sci Transl Med,2010

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