Leveraging large observational studies to discover genetic determinants of drug concentrations: A proof‐of‐concept study-Reference-Cited by-同舟云学术

Leveraging large observational studies to discover genetic determinants of drug concentrations: A proof‐of‐concept study

Published:2022-02-05 Issue:4 Volume:15 Page:1063-1073
ISSN:1752-8054
Container-title:Clinical and Translational Science
language:en
Short-container-title:Clinical Translational Sci

Author:

Meloche Maxime¹²³,Leclair Grégoire¹,Jutras Martin¹,Oussaïd Essaïd²³,Gaulin Marie‐Josée²³,Mongrain Ian²³,Busseuil David²³,Tardif Jean‐Claude²³⁴,Dubé Marie‐Pierre²³⁴,Denus Simon¹²³

Affiliation:

1. Faculty of Pharmacy Université de Montréal Montreal Quebec Canada

2. Montreal Heart Institute Montreal Quebec Canada

3. Université de Montréal Beaulieu‐Saucier Pharmacogenomics Center Montreal Quebec Canada

4. Faculty of Medicine Université de Montréal Montreal Quebec Canada

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/cts.13230

Reference34 articles.

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2. A Meta-Analysis of CYP2D6 Metabolizer Phenotype and Metoprolol Pharmacokinetics

3. Significant interaction between the nonprescription antihistamine diphenhydramine and the CYP2D6 substrate metoprolol in healthy men with high or low CYP2D6 activity

4. Rare and low-frequency coding variants in CXCR2 and other genes are associated with hematological traits

5. The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

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