Affiliation:
1. College of Food Science and Technology Shanghai Ocean University Shanghai 201306 China
2. Human Phenome Institute Fudan University Shanghai 200438 China
3. Shanghai Engineering Research Center of Aquatic‐Product Processing and Preservation Shanghai 201306 China
Abstract
SummaryHigh‐fat‐and‐fructose diet (HFFD) is one of the causes of hyperlipidaemia (HLP), which could directly cause serious diseases that are harmful to human health. The phenolic composition of stevia extract (WeiKe) and its effect of different concentrations on glucose–lipid metabolism, oxidative stress, and intestinal microecology in hyperlipidaemia mice were investigated. The results showed that WeiKe could effectively inhibit the increase in body weight and blood glucose levels and regulate lipid metabolism. WeiKe repaired the gut morphology, promoted short‐chain fatty acid (SCFA) production, and improved food digestion and absorption. Furthermore, WeiKe reduced the Firmicutes/Bacteroidetes ratio and increased the relative abundance of Lactobacillus. These results suggested that stevia extract had a potential modulatory effect on HFFD‐induced HLP.
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