Antioxidant capacity, antitumor activity and metabolomic profile of tamarillo (<i>Solanum betaceum</i>)-Reference-Cited by-同舟云学术

Antioxidant capacity, antitumor activity and metabolomic profile of tamarillo (Solanum betaceum)

Published:2024-07-30 Issue:9 Volume:59 Page:6267-6276
ISSN:0950-5423
Container-title:International Journal of Food Science & Technology
language:en
Short-container-title:Int J of Food Sci Tech

Author:

Silva Luciana de Oliveira¹^ORCID,Rosado Carolyne Pimentel¹^ORCID,Samary Manuela¹^ORCID,Cruz Marta Angela de Almeida Sousa¹^ORCID,Montenegro Júlia¹^ORCID,Silva Giovana Ramalho Patrizi da²^ORCID,Antonio Ananda da Silva³^ORCID,Pereira Henrique Marcelo Gualberto³^ORCID,Veiga‐Junior Valdir Florêncio da⁴^ORCID,Palumbo Antonio⁵^ORCID,Teodoro Anderson Junger²^ORCID,Nunes Juliana Cortes¹^ORCID

Affiliation:

1. Food and Nutrition Master Program (PPGAN), Department of Food Science Federal University of State of Rio de Janeiro, UNIRIO Rio de Janeiro 22290240 Rio de Janeiro Brazil

2. Integrated Center for Food and Nutrition (CIAN) Fluminense Federal University, UFF Niteroi 24020140 Rio de Janeiro Brazil

3. Laboratory for the Support of Technological Development, Chemistry Institute Federal University of Rio de Janeiro Rio de Janeiro 21941‐901 Rio de Janeiro Brazil

4. Department of Chemical Engineering Military Institute of Engineering—IME Rio de Janeiro 22290‐270 Rio de Janeiro Brazil

5. Laboratory of Cellular Interactions, Institute of Biomedical Sciences Federal University of Rio de Janeiro State Rio de Janeiro Rio de Janeiro Brazil

Abstract

SummaryTamarillo (Solanum betaceum), native to the Andes and a PANC in Brazil, contains bioactive compounds with potential anticancer properties in vitro. This study aimed to assess the influence of tamarillo extracts for their antioxidant activity, chemical composition and antiproliferative effects on human prostate cells. Aqueous (AE) and ethanolic extracts (EE) were tested, revealing higher phenolic content and superior antioxidant activity in EE (TPC: 1191.78 ± 28.16 mg GAE/100 g, DPPH: 514.90 μmol TE g−1; FRAP: 150.35 ± 4.42 μmol Fe2SO4 g−1). UPLC‐MS analysis identified twenty‐two compound classes, mainly flavonoids (eleven), carboxylic acids and derivatives (eight), organooxygen compounds (eight) and fatty acyls (seven). Tamarillo extracts significantly reduced cell viability in DU‐145 and PC‐3 cells by almost 60% in 48 h, with PC‐3 cells showing greater resilience and a 30% reduction with EE. Additionally, tamarillo extracts induced cell cycle arrest (G2/M phase) and apoptosis, suggesting their potential as natural antioxidants with protective effects against prostate cancer.

Funder

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

Publisher

Wiley

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