Peripheral and Site-Specific CD4+CD28nullT Cells from Rheumatoid Arthritis Patients Show Distinct Characteristics

Author:

Pieper J.1,Johansson S.1,Snir O.12,Linton L.3,Rieck M.4,Buckner J. H.4,Winqvist ‎O.3,van Vollenhoven R.5,Malmström V.1

Affiliation:

1. Rheumatology Unit; Department of Medicine at Karolinska University Hospital; Karolinska Institute; Solna Stockholm Sweden

2. Centre for Immune Regulation; Department of Immunology; Oslo University Hospital-Rikshospitalet, University of Oslo; Norway

3. Translational Immunology Unit; Department of Medicine at Karolinska University Hospital; Karolinska Institute; Solna Stockholm Sweden

4. Translational Research Program; Benaroya Research Institute at Virginia Mason; Seattle WA USA

5. Unit for Clinical Therapy Research; Inflammatory Diseases; Karolinska Institute; Solna Stockholm Sweden

Publisher

Wiley

Subject

Immunology,General Medicine

Reference42 articles.

1. Modulation of CD28 expression: distinct regulatory pathways during activation and replicative senescence;Vallejo;J Immunol,1999

2. Molecular basis for the loss of CD28 expression in senescent T cells;Vallejo;J Biol Chem,2002

3. Pathogenic features of CD4+CD28- T cells in immune disorders;Broux;Trends Mol Med,2012

4. Down-regulation of CD28 expression by TNF-alpha;Bryl;J Immunol,2001

5. Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages;Schonland;Proc Natl Acad Sci U S A,2003

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