Hypersensitivity reactions to proton pump inhibitors. An <scp>EAACI</scp> position paper-Reference-Cited by-同舟云学术

Hypersensitivity reactions to proton pump inhibitors. An EAACI position paper

Published:2023-11-27 Issue: Volume: Page:
ISSN:0105-4538
Container-title:Allergy
language:en
Short-container-title:Allergy

Author:

Bavbek Sevim¹^ORCID,Kepil Özdemir Seçil²^ORCID,Bonadonna Patrizia³^ORCID,Atanaskovic‐Markovic Marina⁴^ORCID,Barbaud Annick⁵^ORCID,Brockow Knut⁶^ORCID,Laguna Martinez Jose⁷^ORCID,Nakonechna Alla⁸^ORCID,Pagani Mauro⁹^ORCID,Arcolacı Alessandra¹⁰^ORCID,Lombardo Carla¹¹^ORCID,Torres Maria J.¹²^ORCID

Affiliation:

1. Division of Immunology and Allergy, Department of Chest Diseases, School of Medicine Ankara University Ankara Turkey

2. Department of Chest Diseases, Allergy and Immunology Unit, İzmir Faculty of Medicine, Dr. Suat Seren Chest Diseases and Surgery Training and Research Hospital University of Health Sciences İzmir Turkey

3. Allergy Unit Borgo Roma University Hospital Verona Italy

4. Department of Allergology and Pulmonology, Faculty of Medicine University of Belgrade, University Children's Hospital Belgrade Serbia

5. Département de dermatologie et allergologie Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP‐HP, Sorbonne Université, Hôpital Tenon Paris France

6. Department of Dermatology and Allergy Biederstein, Faculty of Medicine Technical University of Munich Munich Germany

7. Allergy Unit, Allergo‐Anaesthesia Unit, Faculty of Medicine, Hospital Central de la Cruz Roja Alfonso X El Sabio University Madrid Spain

8. Allergy and Clinical Immunology Department University of Liverpool, Royal Preston Hospital, Lancashire Teaching Hospitals, NHS Foundation Trust Liverpool UK

9. Medicine Department Medicine Ward Mantova Hospital, ASST di Mantova Mantova Italy

10. Immunology Unit Borgo Roma University Hospital Verona Italy

11. Division of Dermatology and Allergy APSS – Trento Hospital Trento Italy

12. Allergy Unit, Regional University Hospital of Malaga, IBIMA‐UMA‐ARADyAL Malaga Spain

Abstract

AbstractProton pump inhibitors (PPIs) are invaluable therapeutic options in a variety of dyspeptic diseases. In addition to their well‐known risk profile, PPI consumption is related to food and environmental allergies, dysbiosis, osteoporosis, as well as immediate and delayed hypersensitivity reactions (HSRs). The latter, although a rare event, around 1%–3%, due to the extraordinarily high rate of prescription and consumption of PPIs are related to a substantial risk. In this Position Paper, we provide clinicians with practical evidence‐based recommendations for the diagnosis and management of HSRs to PPIs. Furthermore, the unmet needs proposed in the document aim to stimulate more in‐depth investigations in the topic.

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/all.15961

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