A nonparametric mixture approach to density and null proportion estimation in large‐scale multiple comparison problems

Author:

Xue Xiangjie1,Wang Yong1ORCID

Affiliation:

1. Department of Statistics The University of Auckland Private Bag 92019 Auckland 1142 New Zealand

Abstract

SummaryA new method for estimating the proportion of null effects is proposed for solving large‐scale multiple comparison problems. It utilises maximum likelihood estimation of nonparametric mixtures, which also provides a density estimate of the test statistics. It overcomes the problem of the usual nonparametric maximum likelihood estimator that cannot produce a positive probability at the location of null effects in the process of estimating nonparametrically a mixing distribution. The profile likelihood is further used to help produce a range of null proportion values, corresponding to which the density estimates are all consistent. With a proper choice of a threshold function on the profile likelihood ratio, the upper endpoint of this range can be shown to be a consistent estimator of the null proportion. Numerical studies show that the proposed method has an apparently convergent trend in all cases studied and performs favourably when compared with existing methods in the literature.

Publisher

Wiley

Subject

Statistics, Probability and Uncertainty,Statistics and Probability

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3