A prospective, multicenter phase II study of continuous infusion of FLAG for patients older than 60 yr with resistant acute myeloid leukemia: a comparison with intensive younger patients’ trial

Author:

Kim Hawk1,Lee Je-Hwan2,Joo Young-Don3,Bae Sung Hwa4,Lee Jung-Hee2,Kim Dae-Young2,Lee Won-Sik5,Ryoo Hun-Mo4,Jo Jae-Cheol1,Choi Yunsuk1,Lee Kyoo-Hyung2,

Affiliation:

1. Division of Hematology and Cellular Therapy; Ulsan University Hospital; University of Ulsan College of Medicine; Ulsan Korea

2. Department of Hematology; Asan Medical Center; University of Ulsan College of Medicine; Ulsan Korea

3. Department of Hematology/Oncology; Haeundae Paik Hospital; Inje University College of Medicine; Busan Korea

4. Department of Hematology-Oncology; Daegu Catholic University Medical Center; Catholic University of Daegu School of Medicine; Daegu Korea

5. Department of Hematology/Oncology; Busan Paik Hospital; Inje University College of Medicine; Busan Korea

Funder

Ministry of Education, Science and Technology

Publisher

Wiley

Subject

Hematology,General Medicine

Reference22 articles.

1. Trends in the treatment of acute myeloid leukaemia in the elderly;Lang;Drugs Aging,2005

2. Korean Society of Hematology AMLMDSwp. Fludarabine, cytarabine, and attenuated-dose idarubicin (m-FLAI) combination therapy for elderly acute myeloid leukemia patients;Kim;Am J Hematol,2013

3. Pharmacokinetic and pharmacodynamic studies of fludarabine and cytosine arabinoside administered as loading boluses followed by continuous infusions after a phase I/II study in pediatric patients with relapsed leukemias. The Children's Cancer Group;Avramis;Clin Cancer Res,1998

4. Phase I/II study of idarubicin given with continuous infusion fludarabine followed by continuous infusion cytarabine in children with acute leukemia: a report from the Children's Cancer Group;Dinndorf;J Clin Oncol,1997

5. A phase I/II study of idarubicin (Ida) with continuous infusion fludarabine (F-ara-A) and cytarabine (ara-C) for refractory or recurrent pediatric acute myeloid leukemia (AML);Leahey;J Pediatr Hematol Oncol,1997

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