Interleukin-15-activated natural killer cells kill autologous osteoclasts via LFA-1, DNAM-1 and TRAIL, and inhibit osteoclast-mediated bone erosionin vitro

Author:

Feng Shan12,Madsen Suzi H.1,Viller Natasja N.3,Neutzsky-Wulff Anita V.14,Geisler Carsten2,Karlsson Lars1,Söderström Kalle15

Affiliation:

1. Department of Cellular Pharmacology; Autoimmune Disease Research; Novo Nordisk A/S; Måløv Denmark

2. Department of International Health, Immunology and Microbiology, Faculty of Health and Medical Sciences; University of Copenhagen; Copenhagen Denmark

3. Department of Immunopharmacology; Autoimmune Disease Research; Novo Nordisk A/S; Måløv Denmark

4. F. Widjaja Foundation Inflammatory Bowel & Immunobiology Research Institute; IBD Drug Discovery and Development; Cedars-Sinai Medical Center; Los Angeles CA USA

5. Kennedy Institute of Rheumatology; University of Oxford; Oxford UK

Funder

Danish Agency for Science, Technology and Innovation

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

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