Characterization of the heterozygous glucokinase knockout mouse as a translational disease model for glucose control in type 2 diabetes
Author:
Affiliation:
1. CVMD iMed; AstraZeneca; Macclesfield Cheshir UK
2. Oncology iMed; AstraZeneca; Macclesfield Cheshire UK
Publisher
Wiley
Subject
Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/bph.12498/fullpdf
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3. Chronic glucokinase activator treatment at clinically translatable exposures gives durable glucose lowering in two animal models of type 2 diabetes;Baker;Br J Pharmacol,2014
4. Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene;Bali;J Biol Chem,1995
5. Effects of type 2 diabetes on the ability of insulin and glucose to regulate splanchnic and muscle glucose metabolism. Evidence for a defect in hepatic glucokinase activity;Basu;Diabetes,2000
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