1. Department of Physiology and Pharmacology, Faculty of Medicine; Federal University of Ceará; Rua Cel. Nunes de Melo 1127; CEP: 60431-270; Fortaleza; Brazil
2. Laboratory of Pharmaceutics Technology; Federal University of Paraíba; Cidade Universitária, Castelo Branco; CEP: 58051-900; João Pessoa - PB; Brazil