Which experimental design for phase I clinical trials? Proposal for an investigational approach

Author:

Durieu I.,Girard P.,Boissel JP

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference9 articles.

1. Monte-Carlo comparison of three up-and-down designs for dose ranging studies;Bolognese;Controlled Clin Trials,1983

2. The up-and-down methods with small samples;Brownlee;Am Stat Assoc J,1953

3. Durieu I. , Girard P. , Boissel JP (1990) Factors modifying the dose-ranging estimation in phase I studies: a simulation approach. Internal report.

4. Design of phase I and phase II clinical trials;Geller;Cancer Invest,1984

5. The multiple up-and-down methods in bioessay;Hsi;Am Stat Assoc J,1969

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