1. Department of Medical Research Chung Shan Medical University Hospital Taichung Taiwan
2. Institute of Medicine, Chung Shan Medical University Taichung Taiwan
3. School of Dentistry Chung Shan Medical University Taichung Taiwan
4. Department of Dentistry Chung Shan Medical University Hospital Taichung Taiwan
5. Department of Otorhinolaryngology‐Head and Neck Surgery, Changhua Christian Hospital Changhua Taiwan
6. Oral cancer Research Center, Changhua Christian Hospital Changhua Taiwan
7. Institute of Oral Sciences, Chung Shan Medical University Taichung Taiwan