Affiliation:
1. Department of Plastic and Burns Surgery The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital Chengdu China
2. Department of Urology The First Affiliated Hospital of Chengdu Medical College Chengdu China
3. Department of Medical Laboratory Xindu District People's Hospital of Chengdu Chengdu China
4. Department of Cosmetic Plastic and Burns Surgery The First Affiliated Hospital of Chengdu Medical College Chengdu China
5. Department of Orthopedics The Affiliated Hospital of Yangzhou University, Yangzhou University Yangzhou China
Abstract
AbstractSevere burns often have a high mortality rate due to sepsis, but the genetic and immune crosstalk between them remains unclear. In the present study, the GSE77791 and GSE95233 datasets were analysed to identify immune‐related differentially expressed genes (DEGs) involved in disease progression in both burns and sepsis. Subsequently, weighted gene coexpression network analysis (WGCNA), gene enrichment analysis, protein–protein interaction (PPI) network construction, immune cell infiltration analysis, core gene identification, coexpression network analysis and clinical correlation analysis were performed. A total of 282 common DEGs associated with burns and sepsis were identified. Kyoto Encyclopedia of Genes and Genomes pathway analysis identified the following enriched pathways in burns and sepsis: metabolic pathways; complement and coagulation cascades; legionellosis; starch and sucrose metabolism; and ferroptosis. Finally, six core DEGs were identified, namely, IL10, RETN, THBS1, FGF13, LCN2 and MMP9. Correlation analysis showed that some core DEGs were significantly associated with simultaneous dysregulation of immune cells. Of these, RETN upregulation was associated with a worse prognosis. The immune‐related genes and dysregulated immune cells in severe burns and sepsis provide potential research directions for diagnosis and treatment.
Funder
National Natural Science Foundation of China
Subject
Cell Biology,Molecular Medicine
Cited by
1 articles.
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