Endothelial transdifferentiation in hepatocellular carcinoma: loss of Stabilin-2 expression in peri-tumourous liver correlates with increased survival

Author:

Géraud Cyrill1,Mogler Carolin2,Runge Anja3,Evdokimov Konstantin1,Lu Shun1,Schledzewski Kai1,Arnold Bernd4,Hämmerling Günter4,Koch Philipp S.1,Breuhahn Kai2,Longerich Thomas2,Marx Alexander5,Weiss Christel6,Damm Friederike1,Schmieder Astrid1,Schirmacher Peter2,Augustin Hellmut G.3,Goerdt Sergij1

Affiliation:

1. Department of Dermatology, Venereology and Allergology; University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology; Mannheim Germany

2. Institute of Pathology; University Clinic Heidelberg; Heidelberg University; Heidelberg Germany

3. Joint Research Division of Vascular Biology; Medical Faculty Mannheim; Heidelberg University, and German Cancer Research Center Heidelberg; Heidelberg Germany

4. Department of Molecular Immunology; German Cancer Research Center (DKFZ); Heidelberg Germany

5. Department of Pathology; University Medical Center and Medical Faculty Mannheim, Heidelberg University; Mannheim Germany

6. Division for Medical Statistics; Medical Faculty Mannheim; Heidelberg University; Mannheim Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

Hepatology

Reference59 articles.

1. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008;Ferlay;Int J Cancer,2010

2. Early HCC: diagnosis and molecular markers;Sakamoto;J Gastroenterol,2009

3. Anti-angiogenesis in hepatocellular carcinoma treatment: Current evidence and future perspectives;Welker;World J Gastroenterol,2011

4. Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival;Llovet;Hepatology,2003

5. Sorafenib in advanced hepatocellular carcinoma;Llovet;N Engl J Med,2008

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