Affiliation:
1. School of Public Health Capital Medical University Beijing China
2. Beijing Municipal Key Laboratory of Clinical Epidemiology Beijing China
3. Science and Education Section Beijing Physical Examination Center Beijing China
Abstract
AbstractBackground and AimAlthough an association between skeletal muscle mass index and nonalcoholic fatty liver disease (NAFLD) has previously been demonstrated, the causal direction remains unclear. Herein, we investigated the directional association between NAFLD and the serum creatinine‐to‐body weight ratio (sCr/bw), a surrogate marker of the muscle mass index, using longitudinal data.MethodsWe recruited 9662 participants in 2017 and performed follow‐up over 4 years. We evaluated whether sCr/bw was related to NAFLD development (Analysis I) and whether NAFLD was associated with a low sCr/bw incidence (Analysis II) using logistic regression models. Furthermore, a random intercept cross‐lagged panel model was applied to evaluate the bidirectional association between sCr/bw ratio and NAFLD (Analysis III).ResultsAnalysis I demonstrated an association between sCr/bw and incident NAFLD (odds ratio [OR] = 0.160, 95% confidence interval [CI]:0.107–0.232). Analysis II indicated a relationship between NAFLD and subsequent low sCr/bw ratio (OR = 1.524, 95% CI: 1.258–1.846). Analysis III indicated that the standard regression coefficient from sCr/bw to subsequent hepatic steatosis (HS) was −0.053 for βsCr/bw2017 → HS2019 and −0.060 for βsCr/bw2019 → HS2021 and the coefficient from HS to subsequent sCr/bw was −0.093 for βHS2017 → sCr/bw2019 and −0.112 for βHS2019 → sCr/bw2021 (all P < 0.05).ConclusionsThis study indicated mutual causality between sCr/bw and NAFLD. Considering that sCr/bw is a surrogate marker of muscle mass index, the findings emphasize that NAFLD and low muscle mass form a vicious cycle, which should be taken seriously in clinical practice.
Funder
Natural Science Foundation of Beijing Municipality
National Key Research and Development Program of China
Subject
Gastroenterology,Hepatology
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献