Does Secretory Clearance Follow Glomerular Filtration Rate in Chronic Kidney Diseases? Reconsidering the Intact Nephron Hypothesis

Author:

Chapron A1,Shen DD12,Kestenbaum BR3,Robinson-Cohen C3,Himmelfarb J3,Yeung CK32

Affiliation:

1. Department of Pharmaceutics, School of Pharmacy; University of Washington; Seattle Washington USA

2. Department of Pharmacy; School of Pharmacy; University of Washington; Seattle Washington USA

3. Kidney Research Institute, Division of Nephrology, Department of Medicine; University of Washington; Seattle Washington USA

Funder

National Institutes of Health

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Reference50 articles.

1. GFR may not accurately predict aspects of proximal tubule drug handling;Putt;Eur. J. Clin. Pharmacol.,2014

2. Principles and clinical application of assessing alterations in renal elimination pathways;Tett;Clin. Pharmacokinet.,2003

3. Behaviour of chlorpropamide in renal insufficiency and under the effect of associated drug therapy;Petitpierre;Int. J. Clin. Pharmacol.,1972

4. On the meaning of the intact nephron hypothesis;Bricker;Am. J. Med.,1969

5. Drug dosage in renal disease;Dettli;Clin. Pharmacokinet.,1976

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