Overexpression of pregnane X and glucocorticoid receptors and the regulation of cytochrome P450 in human epileptic brain endothelial cells

Author:

Ghosh Chaitali12,Hossain Mohammed1,Solanki Jesal1,Najm Imad M.3,Marchi Nicola4,Janigro Damir56

Affiliation:

1. Cerebrovascular Research; Department of Biomedical Engineering; Lerner Research Institute; Cleveland Clinic; Cleveland Ohio U.S.A.

2. Department of Molecular Medicine; Lerner Research Institute; Cleveland Clinic; Cleveland Ohio U.S.A.

3. Epilepsy Center; Neurological Institute; Cleveland Clinic; Cleveland Ohio U.S.A.

4. Department of Neuroscience; Institute of Functional Genomics; CNRS/INSERM; Montpellier France

5. Flocel, Inc.; Cleveland Ohio U.S.A.

6. Case Western Reserve University; Cleveland Ohio U.S.A.

Funder

National Institutes of Health

Brain and Behavior Research Foundation

American Heart Association

Alternatives Research and Development Foundation

Publisher

Wiley

Subject

Clinical Neurology,Neurology

Reference47 articles.

1. Principles for modulation of the nuclear receptor superfamily;Gronemeyer;Nat Rev Drug Discov,2004

2. Nuclear receptors and drug disposition gene regulation;Tirona;J Pharm Sci,2005

3. Induction of CYP2C genes in human hepatocytes in primary culture;Gerbal-Chaloin;Drug Metab Dispos,2001

4. The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors;Pascussi;Biochim Biophys Acta,2003

5. The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences;Pascussi;Annu Rev Pharmacol Toxicol,2008

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