Pharmacoenhancement of Low Crizotinib Plasma Concentrations in Patients with Anaplastic Lymphoma Kinase‐Positive Non‐Small Cell Lung Cancer using the CYP3A Inhibitor Cobicistat

Author:

Hohmann Nicolas12,Bozorgmehr Farastuk3,Christopoulos Petros3,Mikus Gerd1,Blank Antje1,Burhenne Jürgen1,Thomas Michael3,Haefeli Walter E.1

Affiliation:

1. Department Clinical Pharmacology and Pharmacoepidemiology University Hospital Heidelberg Heidelberg Germany

2. Department of Medical Oncology National Center for Tumor Diseases Heidelberg Germany

3. Department of Thoracic Oncology German Center for Lung Research (DZL) Thorax Clinic at Heidelberg University Hospital Heidelberg Germany

Funder

Dietmar Hopp Stiftung

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Reference20 articles.

1. Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer

2. Crizotinib versus Chemotherapy in AdvancedALK-Positive Lung Cancer

3. Crizotinib: A Review of Its Use in the Treatment of Anaplastic Lymphoma Kinase-Positive, Advanced Non-Small Cell Lung Cancer

4. U.S. Food and Drug Administration.Center for Drug Evaluation and Research. Clinical pharmacology and biopharmaceutics review.https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202570Orig1s000ClinPharmR.pdf(2011). Accessed July 9 2020.

5. Isolated central nervous system progression on Crizotinib

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