Endothelial microparticles released by activated protein C protect beta cells through EPCR/PAR1 and annexin A1/FPR2 pathways in islets

Author:

Kreutter Guillaume1ORCID,Kassem Mohamad12,El Habhab Ali12,Baltzinger Philippe13,Abbas Malak2,Boisrame-Helms Julie14,Amoura Lamia12,Peluso Jean5,Yver Blandine1,Fatiha Zobairi1,Ubeaud-Sequier Geneviève165,Kessler Laurence13,Toti Florence2

Affiliation:

1. EA7293; Vascular and Tissular Stress in Transplantation; Federation of Translational Medicine of Strasbourg; Faculty of Medicine; University of Strasbourg; Illkirch France

2. UMR7213 CNRS; Laboratory of Biophotonics and Pharmacology; Faculty of Pharmacy; University of Strasbourg; Illkirch France

3. Department of Diabetology; University Hospital; CHU de Strasbourg; 1 place de l'Hôpital; Strasbourg Cedex France

4. Department of Anesthesia-Reanimation; University Hospital, CHU de Strasbourg, 1 place de l'Hôpital; Strasbourg Cedex France

5. UPS1401- Plateforme eBiocyte; Faculty of Pharmacy; University of Strasbourg; Illkirch France

6. Department of Pharmacy-sterilization; University Hospital; CHU de Strasbourg; Strasbourg France

Funder

ASDIA (Assistance Service DIAbète) company

University Hospital of Strasbourg

Publisher

Wiley

Subject

Cell Biology,Molecular Medicine

Reference51 articles.

1. Protein C anticoagulant and cytoprotective pathways;Griffin;Int J Hematol,2012

2. The cytoprotective protein C pathway;Mosnier;Blood,2007

3. PROWESS-SHOCK: Drotrecogin alfa (activated) in adults with septic shock;Ranieri;N Engl J Med,2012

4. Cytoprotective-selective activated protein C therapy for ischaemic stroke;Mosnier;Thromb Haemost,2014

5. Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1;Wang;Brain Res,2013

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