Polymorphisms of genes involved in inflammation and blood vessel development influence the risk of varicose veins

Author:

Shadrina A.1ORCID,Tsepilov Y.2,Smetanina M.3,Voronina E.4,Seliverstov E.5,Ilyukhin E.6,Kirienko A.5,Zolotukhin I.7,Filipenko M.4

Affiliation:

1. Laboratory of Pharmacogenomics, Institute of Chemical Biology and Fundamental Medicine, Theoretical and Applied Functional Genomics Laboratory; Novosibirsk State University; Novosibirsk Russia

2. Laboratory of Recombination and Segregation Analysis, Institute of Cytology and Genetics, Theoretical and Applied Functional Genomics Laboratory; Novosibirsk State University; Novosibirsk Russia

3. Laboratory of Pharmacogenomics, Institute of Chemical Biology and Fundamental Medicine, Department of Fundamental Medicine; Novosibirsk State University; Novosibirsk Russia

4. Laboratory of Pharmacogenomics, Institute of Chemical Biology and Fundamental Medicine, Department of Natural Sciences; Novosibirsk State University; Moscow Russia

5. Department of Faculty Surgery; Pirogov Russian National Research Medical University; Moscow Russia

6. Private Surgery Center “Medalp”; Saint Petersburg Russia

7. Department of Faculty Surgery, Pirogov Russian National Research Medical University, Laboratory of Pharmacogenomics; Institute of Chemical Biology and Fundamental Medicine; Novosibirsk Russia

Funder

Russian Ministry of Science and Education, 5-100 Excellence Programme

Russian Science Foundation

Publisher

Wiley

Subject

Genetics (clinical),Genetics

Reference55 articles.

1. Genetics in chronic venous disease;Grant;Phlebology,2017

2. Bell RK Durand EY McLean CY Eriksson N Tung JY Hinds D https://blog.23andme.com/wp-content/uploads/2014/10/Bell_ASHG2014_varicose.pdf

3. Genome-wide association analysis for chronic venous disease identifies EFEMP1 and KCNH8 as susceptibility loci;Ellinghaus;Sci Rep,2017

4. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age;Sudlow;PLoS Med,2015

5. Revision of the CEAP classification for chronic venous disorders: consensus statement;Eklöf;J Vasc Surg,2004

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