Melatonin attenuates (-)-epigallocatehin-3-gallate-triggered hepatotoxicity without compromising its downregulation of hepatic gluconeogenic and lipogenic genes in mice

Author:

Wang Dongxu12,Wei Yaqing1,Wang Taotao3,Wan Xiaochun12,Yang Chung S.24,Reiter Russel J.5,Zhang Jinsong12

Affiliation:

1. State Key Laboratory of Tea Plant Biology and Utilization; School of Tea & Food Science; Anhui Agricultural University; Hefei Anhui China

2. International Joint Research Laboratory of Tea Chemistry and Health Effects; Anhui Agricultural University; Hefei Anhui China

3. Department of Clinical Nutrition; Affiliated Hospital of Jiangsu University; Zhenjiang Jiangsu China

4. Department of Chemical Biology; Ernest Mario School of Pharmacy; Rutgers, The State University of New Jersey; Piscataway NJ USA

5. Department of Cellular and Structural Biology; UT Health Science Center; San Antonio TX USA

Funder

National Natural Science Foundation of China

Tea Project of Anhui Provincial Agriculture Committee

Anhui Major Demonstration Project for Leading Talent Team on Tea Chemistry and Health

Funds of Anhui Provincial Science and Technology Department

Collaborative Innovation Center of Agri-forestry Industry in Dabieshan Area

Anhui Agricultural University

Foundation of AHAU Subject Construction

Publisher

Wiley

Subject

Endocrinology

Reference58 articles.

1. Prevention of chronic diseases by tea: possible mechanisms and human relevance;Yany;Annu Rev Nutr,2013

2. Tea and health: studies in humans;Khan;Curr Pharm Des,2013

3. Novel insights of dietary polyphenols and obesity;Wang;J Nutr Biochem,2014

4. The major green tea polyphenol, (-)-epigallocatechin-3-gallate, inhibits obesity, metabolic syndrome, and fatty liver disease in high-fat-fed mice;Bose;J Nutr,2008

5. Diet supplementation with green tea extract epigallocatechin gallate prevents progression to glucose intolerance in db/db mice;Ortsäter;Nutr Metab (Lond),2012

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