Effect of overexpression of human aldehyde dehydrogenase 2 in LLC-PK1 cells on glyceryl trinitrate biotransformation and cGMP accumulation

Author:

D'Souza Y1,Ji Y1,Bennett BM1

Affiliation:

1. Department of Biomedical and Molecular Sciences; Faculty of Health Sciences; Queen's University; Kingston; Ontario; Canada

Publisher

Wiley

Subject

Pharmacology

Reference42 articles.

1. Requirement for reduced, unliganded hemoprotein for the hemoglobin- and myoglobin-mediated biotransformation of glyceryl trinitrate;Bennett;J Pharmacol Exp Ther,1986

2. Effect of in vitro organic nitrate tolerance on relaxation, cyclic GMP accumulation and guanylate cyclase activation by glyceryl trinitrate and the enantiomers of isoidide dinitrite;Bennett;Circ Res,1988

3. Relationship between biotransformation of glyceryl trinitrate and cyclic GMP accumulation in various cultured cell lines;Bennett;J Pharmacol Exp Ther,1989

4. Biotransformation of organic nitrates and vascular smooth muscle cell function;Bennett;Trends Pharmacol Sci,1994

5. Partially irreversible inactivation of mitochondrial aldehyde dehydrogenase by nitroglycerin;Beretta;J Biol Chem,2008

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