Effect of overexpression of human aldehyde dehydrogenase 2 in LLC-PK1 cells on glyceryl trinitrate biotransformation and cGMP accumulation
Author:
Affiliation:
1. Department of Biomedical and Molecular Sciences; Faculty of Health Sciences; Queen's University; Kingston; Ontario; Canada
Publisher
Wiley
Subject
Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1476-5381.2012.02220.x/fullpdf
Reference42 articles.
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2. Effect of in vitro organic nitrate tolerance on relaxation, cyclic GMP accumulation and guanylate cyclase activation by glyceryl trinitrate and the enantiomers of isoidide dinitrite;Bennett;Circ Res,1988
3. Relationship between biotransformation of glyceryl trinitrate and cyclic GMP accumulation in various cultured cell lines;Bennett;J Pharmacol Exp Ther,1989
4. Biotransformation of organic nitrates and vascular smooth muscle cell function;Bennett;Trends Pharmacol Sci,1994
5. Partially irreversible inactivation of mitochondrial aldehyde dehydrogenase by nitroglycerin;Beretta;J Biol Chem,2008
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