Regioselective oxidation of phospho-NSAIDs by human cytochrome P450 and flavin monooxygenase isoforms: implications for their pharmacokinetic properties and safety
Author:
Publisher
Wiley
Subject
Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1476-5381.2012.01982.x/fullpdf
Reference28 articles.
1. Exploration of catalytic properties of CYP2D6 and CYP3A4 through metabolic studies of levorphanol and levallorphan;Bonn;Drug Metab Dispos,2010
2. Some distinctions between flavin-containing and cytochrome P450 monooxygenases;Cashman;Biochem Biophys Res Commun,2005
3. Differential roles of Arg97, Asp293, and Arg108 in enzyme stability and substrate specificity of CYP2C9;Dickmann;Mol Pharmacol,2004
4. Structural basis for ligand promiscuity in cytochrome P450 3A4;Ekroos;Proc Natl Acad Sci USA,2006
5. Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6;Ellis;J Biol Chem,1995
Cited by 26 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Spontaneously hypertensive rats exhibit increased liver flavin monooxygenase expression and elevated plasma TMAO levels compared to normotensive and Ang II-dependent hypertensive rats;Frontiers in Physiology;2024-04-12
2. The microbiome and cardiovascular disease: Implications in Precision Medicine;Comprehensive Precision Medicine;2024
3. Emerging drug delivery systems with traditional routes – A roadmap to chronic inflammatory diseases;Advanced Drug Delivery Reviews;2023-12
4. Functional evaluation of CYP2C19 and CYP3A4 gene polymorphism on ibuprofen metabolism;Toxicology and Applied Pharmacology;2023-09
5. Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions;Archives of Toxicology;2022-06-01
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3