hERG subunit composition determines differential drug sensitivity
Author:
Affiliation:
1. Safety Pharmacology, Safety Assessment UK, AstraZeneca R&D Alderley Park, Macclesfield, UK
2. Department of Physiology, School of Medicine and Public Health, University of Wisconsin‐Madison, Madison, WI, USA
Publisher
Wiley
Subject
Pharmacology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.2011.01378.x
Reference43 articles.
1. MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac Arrhythmia
2. Guide to Receptors and Channels (GRAC);Alexander SPH;Br. J. Pharmacol,2009
3. Optimisation and validation of a medium-throughput electrophysiology-based hERG assay using IonWorks™ HT
4. Molecular Determinants of Dofetilide Block of HERG K + Channels
5. Molecular Determinants of Inactivation and Dofetilide Block inether a-go-go (EAG) Channels and EAG-Related K+ Channels
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