A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension-Reference-Cited by-同舟云学术

A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension

Published:2019-04 Issue:9 Volume:176 Page:1206-1221
ISSN:0007-1188
Container-title:British Journal of Pharmacology
language:en
Short-container-title:Br J Pharmacol

Author:

Yang Peiran¹,Read Cai¹,Kuc Rhoda E.¹,Nyimanu Duuamene¹,Williams Thomas L.¹,Crosby Alexi²,Buonincontri Guido³,Southwood Mark⁴,Sawiak Stephen J.³,Glen Robert C.⁵,Morrell Nicholas W.²,Davenport Anthony P.¹,Maguire Janet J.¹^ORCID

Affiliation:

1. Experimental Medicine and ImmunotherapeuticsUniversity of Cambridge Cambridge UK

2. Department of MedicineUniversity of Cambridge Cambridge UK

3. Wolfson Brain Imaging Centre, Department of Clinical NeuroscienceUniversity of Cambridge Cambridge UK

4. Department of PathologyPapworth Hospital NHS Foundation Trust Cambridge UK

5. The Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, CambridgeUK and Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London UK

Funder

Medical Research Council

Wellcome Trust

British Heart Foundation

Publisher

Wiley

Subject

Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bph.14603

Reference65 articles.

1. Disruption of PPARγ/β-catenin–mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival