The molecular mechanism of two coreceptor binding site antibodies X5 and 17b neutralizing HIV-1: Insights from molecular dynamics simulation-Reference-Cited by-同舟云学术

The molecular mechanism of two coreceptor binding site antibodies X5 and 17b neutralizing HIV-1: Insights from molecular dynamics simulation

Published:2018-05-18 Issue:1 Volume:92 Page:1357-1365
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:Chem Biol Drug Des

Author:

Zhang Yan¹²³^ORCID,Guo Jingjing⁴,Huang Le¹,Tian Jiaqi¹,Yao Xiaojun³^ORCID,Liu Huanxiang¹³

Affiliation:

1. School of Pharmacy; Lanzhou University; Lanzhou China

2. Guiyang College of Traditional Chinese Medicine; Guiyang China

3. State Key Laboratory of Applied Organic Chemistry and Department of Chemistry; Lanzhou University; Lanzhou China

4. Henan Engineering Research Center of Chiral Hydroxyl Pharmaceutical; School of Chemistry and Chemical Engineering; Henan Normal University; Xinxiang Henan China

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/cbdd.13201/fullpdf

Reference46 articles.

1. Defeating AIDS—advancing global health

2. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

3. A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo

4. The Role of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins in Virus Infection

5. GLYCAM06: A generalizable biomolecular force field. Carbohydrates

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