Dopamine Transporter Neuroimaging as an Enrichment Biomarker in Early Parkinson's Disease Clinical Trials: A Disease Progression Modeling Analysis

Author:

Conrado Daniela J.1,Nicholas Timothy2,Tsai Kuenhi3,Macha Sreeraj3,Sinha Vikram3,Stone Julie3,Corrigan Brian2,Bani Massimo4,Muglia Pierandrea1,Watson Ian A.5,Kern Volker D.1,Sheveleva Elena16,Marek Kenneth7,Stephenson Diane T.1,Romero Klaus1,

Affiliation:

1. Critical Path Institute; Tucson Arizona USA

2. Pfizer Inc; Groton Connecticut USA

3. Merck Sharp & Dohme; North Wales Pennsylvania USA

4. UCB; Brussels Belgium

5. Eli Lilly; Indianapolis Indiana USA

6. University of Arizona; Tucson Arizona USA

7. Institute for Neurodegenerative Disorders; New Haven Connecticut USA

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Reference20 articles.

1. Parkinson's disease;Kalia;Lancet,2015

2. The epidemiology of Parkinson's disease: risk factors and prevention;Ascherio;Lancet Neurol,2016

3. American Academy of Neurology Compelling Statistics. [Internet]. https://www.aan.com/uploadedFiles/Website_Library_Assets/Documents/6.Public_Policy/1.Stay_Informed/4.Public_Policy_Resources/compell.pdf

4. Pharmacological treatment of Parkinson disease: a review;Connolly;JAMA,2014

5. Longitudinal follow-up of SWEDD subjects in the PRECEPT study;Marek;Neurology,2014

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