Pituitary‐related immune adverse events induced by programmed death Protein‐1 inhibitors differ clinically from hypophysitis

Author:

Yang Lijuan1ORCID,Zhang Yao2,Chen Xiaoyu3,Liu Kuanzhi1,Zhou Yaru1,Wang Shuchang1ORCID

Affiliation:

1. Department of Endocrinology The 3rd Hospital of Hebei Medical University Shijiazhuang Hebei China

2. Department of Endocrinology Affiliated Hospital of Hebei University Baoding Hebei China

3. Department of Geriatrics The 3rd Hospital of Hebei Medical University Shijiazhuang Hebei China

Abstract

AbstractObjectiveWe aimed to elucidate the clinical features of pituitary immune‐related adverse events (irAEs) induced by PD‐1 inhibitors in a Chinese cohort and the previous literatures.Patients and Design and MeasurementsWe retrospectively analysed the clinical manifestations, laboratory examination findings, imaging features and treatments of 14 patients with pituitary irAEs caused by PD‐1 inhibitors in our cohort. In addition, we searched PubMed for all English articles on pituitary irAEs induced by PD‐1 inhibitors published from 1950 to 2023. A total of 47 articles were included, and the clinical characteristics of 94 patients with pituitary irAEs induced by PD‐1 inhibitors in these literatures were compared to the characteristics of our cohort.ResultsAmong the 14 patients in our cohort with pituitary irAEs induced by PD‐1 inhibitors, 12 patients (85.71%, 12/14) exhibited isolated ACTH deficiency (IAD), 100.0% (14/14) of the central adrenocortical insufficiency, and 2 patients showed more than one hypothalamic‐pituitary axis injury (14.29%, 2/14). Pituitary magnetic resonance imaging in all the 14 patients showed no pituitary enlargement. In previous studies we reviewed, 82.98% of the total (78/94) presented with pituitary irAEs as IAD, 100.0% (94/94) of the central adrenocortical insufficiency, and 78.33% of the patients showed no abnormality of the pituitary gland (47/60). The pituitary irAEs caused by PD‐1 inhibitors did not involve typical manifestations of hypophysitis, such as pituitary enlargement, headache, visual field defects, and multiple pituitary function impairments in our cohort and the previous literatures.ConclusionIn our study, pituitary immune‐related adverse reactions induced by PD‐1 inhibitors mainly manifested isolated ACTH deficiency rather than hypophysitis.

Funder

Natural Science Foundation of Hebei Province

Publisher

Wiley

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Programmed-cell-death-1-receptor-antagonists;Reactions Weekly;2024-08-31

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3