Affiliation:
1. Department of Gynecology Huzhou Third Municipal Hospital, The Affiliated Hospital of Huzhou University Huzhou China
2. Department of Gynecology and Obstetrics Yiwu Central Hospital Yiwu China
Abstract
AbstractAimTo explore the correlation between Fat mass and objectivity associated gene (FTO) rs9939609 polymorphism and susceptibility to polycystic ovary syndrome.MethodsCase–control studies on the relationship between FTO rs9939609 A/T polymorphism and PCOS were searched in PubMed, EMBASE, and Web of Science according to inclusion and exclusion criteria. STATA 12.0 software was conducted for Meta‐analysis.ResultsNine case–control studies were included, including 1410 cases in PCOS group and 1223 cases in healthy control group. The results of meta‐analysis showed that FTO rs9939609 gene polymorphism was associated with PCOS susceptibility, and the risk of developing PCOS was 1.19 times higher for T alleles carriers than for A alleles carriers, and some similar associations were observed in Asian populations.ConclusionsIn summary, FTO rs9939609 gene polymorphism is significantly associated with PCOS susceptibility, especially in Asian populations.
Reference31 articles.
1. Changes in peripheral mitochondrial DNA copy number in metformin‐treated women with polycystic ovary syndrome: a longitudinal study;Yang PK;Reprod Biol Endocrinol,2020
2. Association of polycystic ovary syndrome phenotypes with adverse pregnancy outcomes after in‐vitro fertilization/intracytoplasmic sperm injection;Wang Q;Front Endocrinol (Lausanne),2022
3. The association between anthropometric parameters and cardiovascular risk indicators in women with polycystic ovarian syndrome;Mirdamadi A;ARYA Atheroscler,2020
4. Controversies in the Pathogenesis, Diagnosis and Treatment of PCOS: Focus on Insulin Resistance, Inflammation, and Hyperandrogenism
5. Single nucleotide polymorphisms of EXOC1, BCL2, CCAT2, and CARD8 genes and susceptibility to cervical cancer in the northern Chinese Han population;Feng Y;Front Oncol,2022