Recombinant factor  VIII Fc fusion protein: extended‐interval dosing maintains low bleeding rates and correlates with von W illebrand factor levels

Author:

Shapiro A. D.1,Ragni M. V.2,Kulkarni R.3,Oldenberg J.4,Srivastava A.5,Quon D. V.6,Pasi K. J.7,Hanabusa H.8,Pabinger I.9,Mahlangu J.10,Fogarty P.11,Lillicrap D.12,Kulke S.13,Potts J.13,Neelakantan S.13,Nestorov I.13,Li S.13,Dumont J. A.13,Jiang H.13,Brennan A.13,Pierce G. F.13

Affiliation:

1. Department of Hematology Indiana Hemophilia and Thrombosis Center Indianapolis INUSA

2. University of Pittsburgh and the Hemophilia Center of Western Pennsylvania Pittsburgh PAUSA

3. Department of Pediatrics and Human Development Michigan State University East Lansing MI USA

4. Institut for Experimental Haematologie und Transfusionsmed Universitaetsklinikum Bonn Bonn Germany

5. Department of Hematology Christian Medical College Vellore India

6. Orthopedic Hemophilia Treatment Center Orthopedic Institute for Children Los Angeles CA USA

7. Barts and the London Comprehensive Care Centre London UK

8. Department of Hematology Ogikubo Hospital Suginami‐Ku Tokyo Japan

9. Universitätsklinik für Innere Medizin I Medizinische Universität Wien Wien Austria

10. Haemophilia Comprehensive Care Centre Faculty of Health Sciences University of the Witwatersrand and NHLS Johannesburg South Africa

11. Penn Comprehensive Hemostasis and Thrombosis Program Hospital of the University of Pennsylvania Philadelphia PA USA

12. Department of Pathology & Molecular Medicine Queen's University Kingston Ontario Canada

13. Biogen Idec Cambridge MA USA

Funder

Biogen Idec

Publisher

Wiley

Subject

Hematology

Reference50 articles.

1. The Hemophilias — From Royal Genes to Gene Therapy

2. Mortality among males with hemophilia: relations with source of medical care. The Hemophilia Surveillance System Project Investigators;Soucie JM;Blood,2000

3. National Hemophilia Foundation.Medical and Scientific Advisory Council (MASAC) recommendation concerning prophylaxis (regular administration of clotting factor concentrate to prevent bleeding) 2007.http://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=57&contentid=1007. Accessed 18 July 2013.

4. Improvements in factor concentrates

5. Experience with estramustine phosphate;Nilsson T;Wis Med J,1976

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