Spatiotemporal development and the regulatory mechanisms of cardiac resident macrophages: Contribution in cardiac development and steady state

Author:

Qin Demeng12,Zhang Ying3,Liu Fang24,Xu Xiang5,Jiang Haiqiang6,Su Zhaoliang24ORCID,Xia Lin127ORCID

Affiliation:

1. Institute of Hematological Disease Jiangsu University Zhenjiang China

2. International Genome Center Jiangsu University Zhenjiang China

3. Department of Biochemistry and Molecular Biology, School of Medicine Jiangsu University Zhenjiang China

4. Institute of Medical Immunology Jiangsu University Zhenjiang China

5. Department of Business Yancheng Blood Center Yancheng China

6. Department of Laboratory Medicine Jiangyin Hospital of Traditional Chinese Medicine Wuxi China

7. Department of Laboratory Medicine Affiliated Hospital of Jiangsu University Zhenjiang China

Abstract

AbstractCardiac resident macrophages (CRMs) are integral components of the heart and play significant roles in cardiac development, steady‐state, and injury. Advances in sequencing technology have revealed that CRMs are a highly heterogeneous population, with significant differences in phenotype and function at different developmental stages and locations within the heart. In addition to research focused on diseases, recent years have witnessed a heightened interest in elucidating the involvement of CRMs in heart development and the maintenance of cardiac function. In this review, we primarily concentrated on summarizing the developmental trajectories, both spatial and temporal, of CRMs and their impact on cardiac development and steady‐state. Moreover, we discuss the possible factors by which the cardiac microenvironment regulates macrophages from the perspectives of migration, proliferation, and differentiation under physiological conditions. Gaining insight into the spatiotemporal heterogeneity and regulatory mechanisms of CRMs is of paramount importance in comprehending the involvement of macrophages in cardiac development, injury, and repair, and also provides new ideas and therapeutic methods for treating heart diseases.

Funder

Natural Science Foundation of Jiangsu Province

National Natural Science Foundation of China

Publisher

Wiley

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3